PREPARATION AND EVALUATION OF IRON OXIDE NANOPARTICLES FOR TREATMENT OF IRON DEFICIENCY ANEMIA


Fahima Hashem, Mohamed Nasr, Yomna Ahmed

Abstract


Objective: The objective of this research was to formulate and evaluate iron oxide nanoparticles for treatment of iron deficiency anemia (IDA).

Methods: Iron oxide nanoparticles were prepared by co-precipitation method and stabilized by coating with folic acid or chitosan. The prepared nanoparticles were characterized in vitro for morphology, particle size, zeta potential, crystallinity and ultraviolet-visible (UV-Vis) absorption. In vivo studies were performed to evaluate the efficacy of the prepared nanoparticles in treating iron-deficient anemic rats compared to the commercial iron product.

Results: In vitro results revealed that particle sizes were 65.95±5 nm, 220.2±12 nm and 295.3±19 nm for uncoated iron oxide nanoparticles, folic acid-coated iron oxide nanoparticles and chitosan coated iron oxide nanoparticles, respectively. UV-Vis absorption spectrum and x-ray diffraction (XRD) patterns confirmed that the prepared nanoparticles were iron oxide nanoparticles. In vivo results indicated that folic acid-coated iron oxide nanoparticles showed effective restorative action, returning haemoglobin (Hb) concentration to normal levels, where not only complete recovery of Hb within short time from the anemic state to the high normal level, but also improved Hb concentrations compared to the commercial iron product.

Conclusion: The results obtained in this research work clearly indicated a promising potential of folic acid-coated iron oxide nanoparticles for the effective treatment of IDA.


Keywords


Iron deficiency anemia, Iron oxide nanoparticles, Folic acid, Chitosan

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About this article

Title

PREPARATION AND EVALUATION OF IRON OXIDE NANOPARTICLES FOR TREATMENT OF IRON DEFICIENCY ANEMIA

Keywords

Iron deficiency anemia, Iron oxide nanoparticles, Folic acid, Chitosan

DOI

10.22159/ijpps.2018v10i1.22686

Date

01-01-2018

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 10, Issue 1, 2018 Page: 142-146

Online ISSN

0975-1491

Statistics

52 Views | 64 Downloads

Authors & Affiliations

Fahima Hashem
Professor of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Helwan University, Cairo, Egypt
Egypt

Mohamed Nasr
Professor of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Helwan University, Cairo, Egypt
Egypt

Yomna Ahmed
Graduate student at the department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Helwan University, Cairo, Egypt
Egypt


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