VOLTAMMETRIC DETERMINATION OF DESLORATADINE IN PHARMACEUTICAL AND HUMAN URINE SAMPLES USING GLASSY CARBON ELECTRODE

  • D. Sri Vidya Electroanalytical Lab, Department of Chemistry Sri Venkateswara University, Tirupati-517502, Andhra Pradesh, India
  • M. Siva Prasad Electroanalytical Lab, Department of Chemistry Sri Venkateswara University, Tirupati-517502, Andhra Pradesh, India
  • M. Vishnu Priya Electroanalytical Lab, Department of Chemistry Sri Venkateswara University, Tirupati-517502, Andhra Pradesh, India
  • K Roja Electroanalytical Lab, Department of Chemistry Sri Venkateswara University, Tirupati-517502, Andhra Pradesh, India
  • N.y Sreedhar Electroanalytical Lab, Department of Chemistry Sri Venkateswara University, Tirupati-517502, Andhra Pradesh, India

Abstract

Objective: The electrochemical behaviour of Desloratadine (DLTD) in pharmaceutical and human urine samples at glassy carbon electrode was investigated by cyclic voltammetry (CV) and square wave voltammetry (SWV).

Methods: A well defined reduction peak was observed at potential -1.55V in phosphate buffer solution (PBS) in basic medium. The reduction process was observed to be irreversible over the pH range from pH 2.0 to pH 10.0. The influence of different parameters such as the effect of pH, scan rate and concentration of the drug was studied. The probable reaction mechanism involved in the reduction of DLTD was also proposed. A SWV method with good recovery and accuracy was obtained for the determination of DLTD in pharmaceutical formulations and urine samples.

Results: The peak currents were found to be linearly dependent on the concentration range of 2.55x10-5to 1.5x10-3M of DLTD. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 2.75x 10-9M, 3.20x 10-7 M respectively.

Conclusion: The proposed method was successfully applied for determination of DLTD in pharmaceutical and human urine samples.

 

Keywords: Desloratadine, Cyclic voltammetry, Square wave voltammetry, Glassy carbon electrode, Phosphate buffer.

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How to Cite
Vidya, D. S., M. S. Prasad, M. V. Priya, K. Roja, and N. Sreedhar. “VOLTAMMETRIC DETERMINATION OF DESLORATADINE IN PHARMACEUTICAL AND HUMAN URINE SAMPLES USING GLASSY CARBON ELECTRODE”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 6, no. 10, 1, pp. 119-22, https://innovareacademics.in/journals/index.php/ijpps/article/view/2336.
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