COMPRESSIONAL PROPERTIES OF METRONIDAZOLE TABLET FORMULATIONS CONTAINING ALOE VERA AS BINDING AGENT
The purpose of the present work was to determine the compressional characteristics of metronidazole tablet containing Aloe vera as a binding agent. Metronidazole tablet formulations were prepared using Aloe vera mucilage as a binder at different concentrations (1-5%w/w) and this was compared with formulations containing polyvinyl pyrrolidone (PVP) as a standard. The tablet properties were assessed using friability, crushing strength and disintegration time while compressional characteristics were analysed using density measurements, Heckel and Kawakita equations. The tablet properties conformed to the Pharmacopoeia standards. Tablets formulated with PVP were generally stronger than tablets made from Aloe Vera. All the batches passed the friability tests and the percentage friability decreased with increase in binder concentration. Formulations containing Aloe Vera disintegrated faster than those containing PVP. Tablets containing Aloe Vera exhibited a faster onset of plastic deformation during compression as indicated by the low Pyvalues and a lower degree of total plastic deformation. Results suggest that Aloe Vera could be a useful binding agent in pharmaceutical formulations.
2. Bamiro OA, Sinha VR, Kumar R, Odeku OA. Characterization and evaluation of Terminalia randii gum as a binder in carvedilol tablet formulation. Acta Pharm Sci 2010;52:254-62.
3. Odeku OA, Itiola OA. Evaluation of the effects of Khaya gum on the mechanical and release properties of paracetamol tablet formulation. Drug DevInd Pharm 2003;29:311-20.
4. Singh AK, Shingala VK, Selvam RP, Sivakumar T. Evaluation of MagniferaIndica as tablet binder. Int J Pharm Tech Res 2010;2(3):2098-100.
5. Okorie O, Oreh NC. Evaluation of aloebarbadensis (aloe vera) gum as a binder in tablet formulations. Scientia Afr 2010;9(2):119-25.
6. Heckel RW. Density-pressure relationships in powder compaction. Trans Metal Soc AIME 1961;221:671-5.
7. KawakitaK, Ludde KH. Some considerations on powder compression equations. Powder Technol 1970/71;4:61-8.
8. Hersey JA, Rees JE. Deformation of Particles during briquetting. Nat Phy Sci 1970;230:95-9.
9. Nokhodchi A. An overview of the effect of moisture on compaction and compression. Pharm Tech 2005;1:46-66.
10. Humbert-Droz P, Gurny R, Mordier D, Doelker E. Densification behaviour of drugs presenting availability problems. Int J Pharm Tech Prod Mfr 1983;4:29-35.
11. Shivanand P, Sprockel OL. Compaction behaviour of cellulose polymers. Powder Technol 1992;69:177-84.
12. Lin C, Cham T. Compression behaviour and tensile strength of heat-treated polyethylene glycols. Int J Pharm 1995;118:169-79.
13. Alderborn G. Tablets and Compaction. In Pharmaceutics: The Science of Dosage form Design. Aulton M. E (ed) 2nded: Churchill Livingstone Edinburg; 2002. p. 397-440.
14. Celik, M. Overview of compaction data analysis techniques. Drug Dev Ind Pharm 1992;18:767-810.
15. Okunlola A, Odeku OA. Compressional characteristics and tableting properties of starches obtained from four discorea species. Farmacia 2009;57(6):756-70.
16. Oyi AR, Allagh TS, Olayemi OJ. Comparative binding effects of wheat, rice and maize starches in chloroquine phosphate tablet formulations. Res J Appl Sci Engr Tech 2009;1(2):77-80.
17. Staniforth J. Powder flow, In: Aulton ME. (ed.), Pharmaceuticsâ€“the science of dosage form design. 2nd ed. Churchill Livingstone London; 2002. p. 197â€“210.
18. Abdulsamad A, Isah AB, Bathia PG, Kenneth A. Comparative evaluation of tablet binding properties of cashew (Anacardiumoccidentale L.) gum in Metronidazole tablet formulation. Best J 2008;l5(2):140-5.
19. British Pharmacopoaeia (BP). The Commission Office London 2009;111:6578-85.
20. Uhumwangho MU, Okor RS, Eichie FE, Abbah CM. Influence of some starch binders on the brittle fracture tendency of paracetamol tablets. Afri J Biotechnol 2006;5(20):1950-3.
21. Odeku OA, Itiola OA. Evaluation of Khaya gum as a binder in a Paracetamol tablet formulation. Pharm Pharmacol Commun 1998;4:183-8.