DEVELOPMENT OF ANTI-WRINKLE CREAM FROM PUERARIA CANDOLLEI VAR. MIRIFICA (AIRY SHAW AND SUVAT.) NIYOMDHAM, “KWAO KRUA KAO” FOR MENOPAUSAL WOMEN

  • Panee Sirisa-ard Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand
  • Nichakan Peerakam Faculty of Pharmaceutical Sciences, Burapha University, Chonburi 20130, Thailand
  • Nguyen Quoc Huy Hanoi University of Pharmacy, Hanoi city, Vietnam
  • Tran Van On Hanoi University of Pharmacy, Hanoi city, Vietnam
  • Phung Tuan Long Ministry of Science and Technology (MOST), Hanoi, Vietnam
  • Aekkhaluck Intharuksa Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand

Abstract

Objective: The aim of this study was to incorporate Peraria candollei var. mirifica extract into the cream, to evaluate the physical properties and to conduct the skin tests in participants.

Methods: Pueraria candollei var. mirifica was extracted with 95% ethanol to obtain crude pueraria extract (PCM). Crude PCM was developed as an anti-wrinkle PCM cream (B) intended for menopausal women. PCM cream was evaluated for stability of pH and viscosity, primary skin irritation, wrinkle reduction and moisturizing as well as customer satisfaction. Cream base (A) and cream purchased from the market (C) were used for comparison. ANOVA post hoc Turkey was used to analyze the variance (p0.05) of the mean comparisons between groups by cluster analysis. 

Results: The PCM cream appeared as white color, pH was 6.80, and viscosity was 4.069±0.01 Pa. s, as well as physical characteristic and texture, were acceptable and no irritating reaction. PCM cream exhibited a similar level of moisturizer as cream A and C. The PCM cream revealed an ability to decrease the wrinkle surface and wrinkle volume after applied for 7 and 14 d that shows the activity of this product performed from the PCM extract. Satisfaction of PCM cream showed good acceptance.

Conclusion: These results suggest that PCM cream has the ability to reduce skin wrinkles. It is a good product for postmenopausal women and may also be of benefit for the general population for protection skin wrinkle.

Keywords: Peraria candollei var. mirifica, Anti-skin wrinkle cream, Menopausal woman

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Author Biographies

Panee Sirisa-ard, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand
Assoc. Prof. Dr.
Nichakan Peerakam, Faculty of Pharmaceutical Sciences, Burapha University, Chonburi 20130, Thailand
Dr.
Nguyen Quoc Huy, Hanoi University of Pharmacy, Hanoi city, Vietnam
Assoc Prof. Doc.
Tran Van On, Hanoi University of Pharmacy, Hanoi city, Vietnam

Department of Botany,

Assoc. Prof. Doctor.

Phung Tuan Long, Ministry of Science and Technology (MOST), Hanoi, Vietnam
Mr.
Aekkhaluck Intharuksa, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand

Department of Pharmaceutical Sciences.

Doctor.

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Sirisa-ard, P., N. Peerakam, N. Q. Huy, T. V. On, P. T. Long, and A. Intharuksa. “DEVELOPMENT OF ANTI-WRINKLE CREAM FROM PUERARIA CANDOLLEI VAR. MIRIFICA (AIRY SHAW AND SUVAT.) NIYOMDHAM, “KWAO KRUA KAO” FOR MENOPAUSAL WOMEN”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 10, no. 7, July 2018, pp. 16-21, doi:10.22159/ijpps.2018v10i7.24665.
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