DEVELOPMENT OF ANTI-WRINKLE CREAM FROM PUERARIA CANDOLLEI VAR. MIRIFICA (AIRY SHAW AND SUVAT.) NIYOMDHAM, KWAO KRUA KAO†FOR MENOPAUSAL WOMEN
DOI:
https://doi.org/10.22159/ijpps.2018v10i7.24665Keywords:
Peraria candollei var mirifica, Anti-skin wrinkle cream, Menopausal womanAbstract
Objective: The aim of this study was to incorporate Peraria candollei var. mirifica extract into the cream, to evaluate the physical properties and to conduct the skin tests in participants.
Methods: Pueraria candollei var. mirifica was extracted with 95% ethanol to obtain crude pueraria extract (PCM). Crude PCM was developed as an anti-wrinkle PCM cream (B) intended for menopausal women. PCM cream was evaluated for stability of pH and viscosity, primary skin irritation, wrinkle reduction and moisturizing as well as customer satisfaction. Cream base (A) and cream purchased from the market (C) were used for comparison. ANOVA post hoc Turkey was used to analyze the variance (p0.05) of the mean comparisons between groups by cluster analysis.Â
Results: The PCM cream appeared as white color, pH was 6.80, and viscosity was 4.069±0.01 Pa. s, as well as physical characteristic and texture, were acceptable and no irritating reaction. PCM cream exhibited a similar level of moisturizer as cream A and C. The PCM cream revealed an ability to decrease the wrinkle surface and wrinkle volume after applied for 7 and 14 d that shows the activity of this product performed from the PCM extract. Satisfaction of PCM cream showed good acceptance.
Conclusion: These results suggest that PCM cream has the ability to reduce skin wrinkles. It is a good product for postmenopausal women and may also be of benefit for the general population for protection skin wrinkle.
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References
FDA. Origin and description of Pueraria mififica. Available from: http://www.fda.gov/ohrms/dockets/dockets/95s0316/95s-0316-rpt0224-13-Tab-II-Origin-and-Description-of-Pueraria-Mirifica-vol162.pdf [Last accessed 10 Oct 2015]
Suntara A. The remedy pamphlet of kwao krua tuber of laung anusarnsuntara-kromarnphiset. Chiang Mai, Thailand: Chiang Mai Upatipongsa Press; 1931.
Pope GS, Grundy HM, Jones HEH, Tait SAS. The estrogenic substance (miroestrol) from the tuberous roots of Pueraria mirifica. J Endocrinol 1958;17:15-6.
Tayler NE, Hodgkin DC, Rollett JS. The X-ray crystallographic determination of the structure of bromomiroestrol. J Chem Soc 1960;33:3685.
Chansakaow S, Isikawa T, Seki H, Sekine K, Okada M, Chaichantipyuth C. Identification of deoxymiroestrol as the actual rejuvenating principle of ‘‘Kwao Keur,’’ Pueraria mirifica. The known miroestrol may be an artifact. J Nat Prod 2000a;63:173–5.
Chansakaow S, Ishikawa T, Sekine K, Okada M, Higuchi Y, Kudo M, et al. Isoflavonoids from Puerariamirifica and their estrogenic activity. Planta Med 2000b;66:572–5.
Benson GK, Cowie AT, Hosking ZD. Mammogenic activity of miroestrol. J Endocrinol 1961;21:401.
Udomsak L, Juengwatanatrakul T, Putalun W, Jarukamjorn K. Biomodal action of miroestrol and deoxymiroestrol, phytoestrogens from Pueraria candollei var. mirifica on hepatic CYP2B9 and CYP1A2 expressions and anti-lipid peroxidation in mice. Nutr Res 2012;32:45-51.
Udomsak L, Juengwatanatrakul T, Putalun W, Jarukamjorn K. Suppression of BSEP and MRP2 in mouse liver by miroestrol and deoxymiroestrol isolated from Puerariacandollei. Phytomedicine 2012;19:1332-5.
Udomsuk L, Juengwattanatrakul T, Jarukamjorn K, Putalun W. Increased miroestrol, deoxymiroestrol and isoflavonoid accumulation in callus and cell suspension cultures of Pueraria condollie var. mirifica. Acta Physiol Plant 2012;34:1093-100.
Cherdshewasart W, Sutjit W. Correlation of antioxidant activity and major isoflavonoid contents of the phytoestrogen-rich Pueraria mirifica and Pueraria lobate tubers. Phytomedicine 2008;15:38-43.
Lee CH, Yang L, Xu JZ, Yeung SYV, Haung Y, Chen ZY. Relative antioxidant activity of soybean isoflavones and their glycosides. Food Chem 2005;90:735-41.
Cherdshewasart W, Subtang S, Dahlan W. Major isoflavonoid contents of the phytoestrogen rich-herb Pueraria mirificain comparison with Pueraria lobate. J Pharm Biomed Anal 2007b;43:428-34.
Haferkamp MR. Environmental factors affecting plant productivity. Fort Keogh Research Symposium; 1987. p. 27-32.
Dweck AC. FLS FRSC FRSH. The Pueraria family with special in interest in Pueraria mirifica. Personal Care Magazine 2000;3:7-10.
Cherdshewasart W. Extraction derived from Pueraria mirifica, Butea Superba and/or Mucuna collettii and extraction thereof; 2004.
Active Concepts. ABS Puerari amirifica extracts PF efficacy data. Available from:http://activeconceptsllc.com/wp-content/ uploads2015/02Efficacy-Dock-Sheet2pdf. [Last accessed on 10 Dec 2018].
Suwanvesh N, Manonai J, Sophonsritsuk A, Cherdshewasart W. Comparison of Pueraria mirifica gel and conjugated equine estrogen cream effect on vaginal health in postmenopausal women. Menopeuse 2017;24:210-5.
Bashir SJ, Maibach HI. In vivo Irritation. In: Paye M, Barel AO, Maibach HI. Eds. Handbook of Cosmetic Science and Technology. 2nd Edn. Taylorand Francis Group, New York; 2001. p. 905-16.
Jaroenporn S, Urasopon N, Watanabe G, Malaivijitnond S. Improvements of vaginal atrophy without systemic side effects after topical application of Pueraria mirifica, a phytoestro-rich Herb, in postmenopausal cynomolgus macaques. J Repord Dev 2014;60:238-45.
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