PRESCRIPTION PATTERN OF PROPHYLACTIC ANTIMICROBIAL AGENTS USED IN PREOPERATIVE PATIENTS AT A TERTIARY CARE TEACHING HOSPITAL
Objective: This study was designed to analyze the prescription pattern of prophylactic antimicrobial agents used in preoperative patients.
Methods: A descriptive observational study was done at a tertiary care teaching hospital in Potheri from July to December 2013 after obtaining of Institutional Ethics Committee clearance.
Results: Total 284 patients were included in this study, out of which 141(49.6%) were females and 143(50%) were males. In the department of general surgery, the very commonly used antimicrobial agents were cefotaxime (81%) followed by cefoperazone sodium (42%). In the orthopaedics department, the frequently used antimicrobial agents were cefoperazone and sulbactam (39%) followed by cefazolin (29%). Most commonly used antimicrobial agent was cefotaxime (100%) in gynaecology department.
Conclusion: Antimicrobial prophylaxis is helpful in declining the frequency of post-operative infections. This study explained about the various antimicrobial agents used prior to surgeries. Practitioners must prescribe an antibiotic based on their hospital antibiotic policy.
2. Mangram AJ, Horan TC, Pearson ML. Guideline for prevention of surgical site infection. Hospital Infection Control Practices Advisory Committee. Infect Controlled Hosp Epidemiol 1999;20:250-78.
3. Anusha S, Vijaya LD, Pallavi K, Manna PK, Mohanta GP, Manavalan R. An epidemiological study of surgical wound infections in a surgical unit of tertiary care teaching hospital. Indian J Pharm Practice 2010;3:8-13.
4. Haley RW. The scientific basis for using surveillance and risk factor data to reduce nosocomial infection rates. J Hosp Infect 1995;30:3-14.
5. Alan R Salkind, Kavitha C Rao. Antibiotic prophylaxis to prevent surgical site infections. American Family Physician 2011;83:585-90.
6. Bishnu Rath Giri, Hom Prasad Pant, P Ravi Shankar, Chandrasekhara T Sreeramareddy, Pranav Kumar Sen. Surgical site infection and antibiotics use pattern in a tertiary care hospital in Nepal. J Pak Medical Association 2008;58:148-51.
7. Rizvi M, Rizvi MW, Shaheen. The emergence of coryneform bacteria as pathogens in nosocomial surgical site infections in a tertiary care hospital of North India. J Infect Public Health 2013;6:283â€“8.
8. Anand Saxena, Mahendra Pratap Singh, Swagata Brahmachari, Malay Banerjee. Surgical site infection among postoperative patients of tertiary care centre in the central india-a prospective study. Asian J Biomed Pharm Sci 2013;3:41-4.
9. Rosenthal VD, Richtmann R, Singh S. Surgical site infections, International Nosocomial Infection Control Consortium (INICC) report, data summary of 30 countries, 2005â€“2010. Infect Control Hosp Epidemiol 2013;34:597â€“604.
10. Satyanarayana V. Study of surgical site infections in abdominal surgeries. J Clin Diagnostic Res 2011;5:935-9.
11. Alphonso N, Anagnostopoulos PV, Scarpace S. Perioperative antibiotic prophylaxis in paediatric cardiac surgery. Cardiol Young 2007;17:12-25.
12. Maher KO, Van Der Elzen K, Bove EL. A retrospective review of three antibiotic prophylaxis regimens for pediatric cardiac surgical patients. Ann Thorac Surg 2002;74:1195-200.
13. Dale W Bratzler, E Patchen Dellinger, Keith M Olsen, Trish M Perl, Paul G Auwaerter, Maureen K Bolon, et al. Clinical practice guidelines for antimicrobial prophylaxis in surgery. Am J Health Syst Pharm 2013;70:195-283.
14. Garcia Rodriguez JA, Puig LaCalle J, Arnau C, Porta M, Vallve C. Antibiotic prophylaxis with cefotaxime in gastroduodenal and biliary surgery. Am J Surg 1989;158:428-33.
15. Woodfield JC, Van Rij AM, Pettigrew RA, van der Linden AJ, Solomon C, Bolt D. A comparison of the prophylactic efficacy of ceftriaxone and cefotaxime in abdominal surgery. Am J Surg 2003;185:45-9.
16. Jonothanj Earnshaw F. Risk factors in vascular surgical sepsis. Annals of the Royal College of Surgeons of England; 1988. p. 70.
17. Adrienne J Headley. Necrotizing soft tissue infections: a primary care review. Am Family Physician 2003;68:323-8.
18. Nikhil Peter, Nissycherian, Sagythomas, Snehageorge, Junior sundresh N. Study of prescribing pattern and use of antibiotic in the management of wound infection. Asian J Pharm Clin Res 2017;10:210-3.
19. CS Brethis, S Thamizharasan, SA Sridevi, B Kalaiselvi, M Balaji Singh, K Vijaykumar. A prospective study of the pattern of use of antimicrobial agents in surgical prophylaxis in a tertiary care centre. Int J Pharm Pharm Sci 2017;9:283-7.
20. Amol M Valvi, Arun R Mahale, Pankaj N Baravkar. How many antibiotics for cesarean section and hysterectomy: short course versus long course. Int J Reprod Contracept Obstet Gynecol 2014;3:394-7.