• Gihani Jayaweera Department of Basic Sciences, Faculty of Allied Health Sciences, General Sir John Kotelawela Defence University, Sri Lanka
  • Thamasi Makuloluwa Department of Clinical Sciences, Faculty of Medicine, General Sir John Kotelawela Defence University, Sri Lanka
  • Kamal Perera Faculty of Medicine, General Sir John Kotelawela Defence University, Sri Lanka
  • Jeeva K. Amararatne Bestcare Animal Hospital, Nugegoda, Sri Lanka
  • Sirimal Premakumara Industrial Technology Institute, Sri Lanka
  • Daya Ratnasooriya Department of Basic Sciences, Faculty of Allied Health Sciences, General Sir John Kotelawela Defence University, Sri Lanka


Objective: Cinnamomum zeylanicum Blume is claimed in Sri Lankan traditional medicine as a diuretic. Diuretics that are in current use possess serious adverse effects. Thus, there is a need for discovering efficacious and safe diuretics possibly from natural sources. Hence, the study was carried out to scientifically evaluate the diuretic potential of Cinnamomum zeylanicum Blume in vivo.

Methods: Wistar albino rats weighing 180-270 g of either sex were divided into five groups containing six subjects in each. All were starved for 18 h and hydrated subsequently with oral sodium chloride solution (0.9%). Group, I (control) received normal saline (15 ml per animal orally). Group II, III, and IV received different doses (1500, 2250, 3000 mg/kg) of freeze-dried hot water extract of Cinnamomum zeylanicum Blume orally. Group V; (standard) received furosemide (13 mg/kg). Rats were placed individually in metabolic cages. Cumulative urine outputs at hourly intervals for six hours, urinary Na+, K+, Cl-, HCO3-, specific gravity, pH and total dissolved solids were determined.

Results: A strong dose-dependent diuretic activity with a rapid onset of action, rapid peak diuresis and short duration of action was observed compared to furosemide. The diuretic action was accompanied with a significant (p<0.05) increase in urinary Na+, HCO3- and pH and decrease in urinary H+.

Conclusion: The results indicated that hot water extract of Cinnamomum zeylanicum Blume possesses marked diuretic action compared to furosemide. This is mediated primarily via loop diuretic mechanism similar to furosemide and partly by carbonic anhydrase inhibitory action.

Keywords: Cinnamon, Cinnamomum zeylanicum, Water extract, Diuretic, Urine output, Loop diuretic, Thiazide diuretic


Download data is not yet available.


1. Anonymous. WHO monographs on selected medicinal plants. Geneva (SZ). World Health Organization; 1999.
2. Ranasinghe P, Pigera S, Premakumara GS, Galappaththy P, Constantine GR, Katulanda P. Medicinal properties of “true”cinnamon (Cinnamomum zeylanicum): a systematic review. BMC Complement Altern Med 2013;13:275.
3. Kawatra P, Rajagopalan R. Cinnamon: mystic powers of a minute ingredient. Pharmacogn Res 2015;7:1–6.
4. Ziegenfuss T, Hofheins J, Mendel R, Landis J, Anderson R. Effects of a water-soluble cinnamon extract on body composition and features of the metabolic syndrome in pre-diabetic men and women. J Int Soc Sports Nutr 2006;3:45–53.
5. Rao P, Gan S. Cinnamon: a multifaceted medicinal plant. Evid-Based Complement Alt Med 2014:1–12. http://dx.doi.org/ 10.1155/2014/642942.
6. Balijepalli M, Buru A, Sakirolla R, Pichika M. Cinnamomum genus: a review on its biological activities. Int J Pharm Pharm Sci 2017;9:1–11.
7. Maheshwari R, Chauhan A, Gupta A, Sharma S. Cinnamon: an imperative spice for human comfort. Int J Pharm Res Biosci 2013;2:131–45.
8. Monashi D, Suvra M, Budhimanta M, Jayram H. Ethanobotany, phystochemical and pharmacological aspects of Cinnamomum zeylanicum Blume. Int Res J Pharm 2013;4:58–64.
9. Anilakumar K, Naveen J. Cinnamon-a promising spice with nutraceutical properties. World J Pharm Res 2016;5:453–66.
10. Tarranum A, Malhotra U, Ghildiyal A, Chandola P. Antimicrobial activity of plants (Cinnamomum zeylanicum, Cedrus deodara, Eucalyptus globulus, Rosmarinus officinalis) essential oils against some bacterial and fungal strains. Octa J Biosci 2014;2:49-52.
11. Hamidpour R, Hamidpour M, Hamidpour S, Shahlari M. Cinnamon from the selection of traditional applications to its novel effects on the inhibition of angiogenesis in cancer cells and prevention of Alzheimer’s disease, and a series of functions such as antioxidant, anticholesterol, antidiabetes, antibacterial, antifungal, nematicidal, acaracidal, and repellent activities. J Trad Complem Med 2015;5:66–70.
12. Samarasekera R, Kalhari KS, Weerasinghe IS. The mosquitocidal activity of leaf and bark essential oils of Ceylon Cinnamomum zeylanicum. J Essent Oil Res 2005;17:301–3.
13. Ranasinghe P, Jayawardana R, Galappaththy P, Constantine G, Gunawardana N, Katulanda P. Efficacy and safety of “true” cinnamon (Cinnamomum zeylanicum) as a pharmaceutical agent in diabetes: a systematic review and meta-analysis: efficacy and safety of “true” cinnamon in diabetes. Diabet Med 2012;29:1480–92.
14. Gruenwald J, Freder J, Armbruester N. Cinnamon, and health. Crit Rev Food Sci Nutri 2010;50:822–34.
15. Abeysekera W, Premakumara G, Ratnasooriya WD. In vitro antioxidant properties of leaf and bark extracts of ceylon cinnamon (Cinnamomum zeylanicum Blume). Trop Agric Res 2013;24:128–38.
16. Weragoda PB. Osuthuru visithuru. Colombo (SL): Department of Ayuruveda; 1994.
17. Sayana S, Christina, Medabala T, Patil P. Study of diuretic activity of ethonolic extract of leaves of Cissampelos pareira in rats. Asian J Pharm Clin Res 2014;7:157–9.
18. Maura H, Kumar T. A review on comprehensive overview in the management of nephrotic disorders. J Crit Rev 2016;3:34–43.
19. Mohandas R, Chandrashekar R, Manohar V, Kateel R. Potent and efficacious diuretic activity with the potassium-sparing effect of Terminalia belerica fruit pulp aqueous extract in Wistar albino rats. Asian J Pharm Clin Res 2016;9:241–3.
20. Weinberger M. Diuretics and their side effects. Dilemma in the treatment of hypertension. Hypertension 1998;11:16–20.
21. Anonymous. Guiding principles in the use of animals in toxicology, Council Directives 86/609/EEC of 24 November 1986, Society of Toxicology, Reston, Virginia; 2008. p. 1-4.
22. Abeywickrama KRW, Ratnasooriya WD, Amarakoon AMT. Oral diuretic activity of hot water infusion of Sri Lankan black tea (Camellia sinensis L.) in rats. Pharmacogn Mag 2010;6:271–7.
23. Ratnasooriya WD, Muthunayake TBS, Indeesha EK, Ratnasooriya CDT. Oral diuretic activity of Sri Lankan low grown orange pekoe grade black tea (Camellia sinensis L.) in rats. Int J Bioassays 2013;2:286–93.
24. Wile D. Diuretics: a review. Ann Clin Biochem 2012;49:419–31.
25. Katzung B, Masters S, Trevory A. Basic clinical pharmacology. 12th ed. New Delhi (IND): McGraw-Hill Education; 2012.
26. Bhardwaj S, Balgir P, Goel R. Pharmacogenomics and personalized management of hypertension. J Crit Rev 2015; 2:1-6.
131 Views | 236 Downloads
How to Cite
Jayaweera, G., T. Makuloluwa, K. Perera, J. K. Amararatne, S. Premakumara, and D. Ratnasooriya. “ORAL DIURETIC ACTIVITY OF HOT WATER EXTRACT OF H-GRADE QUILLS OF CINNAMOMUM ZEYLANICUM BLUME IN RATS”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 10, no. 10, Oct. 2018, pp. 114-8, doi:10.22159/ijpps.2018v10i10.25200.
Original Article(s)