ANTIOXIDANT AND ANTHELMINTIC POTENTIAL OF THE STEM & LEAVES OF WHITE ABRUS

  • Alby Alphons Baby St. Mary's College, Thrissur, Kerala
  • Regi Raphael K St. Mary's College, Thrissur, Kerala.

Abstract

Introduction: World Health Organization (WHO) appreciates the importance of medicinal plants for public health care in developing nations. White Abrus (Abrus precatorius Linn) have important role in traditional medicine, its seeds, bark, leaves and stem are medicinal.

Objective: The potential of the leaves and stem of this plant as an antioxidant and anthelmintic agents were evaluated.

Methods: All the analysis was done according to standard protocols.

Results: The methanolic extract produced significant anthelmintic and antioxidant properties in a dose-dependent manner. DPPH free radical scavenging assay of leaf and stem exhibited IC 50 values of 275 ±0.83 μg/ml and 170 ± 0.90 μg/ml respectively. At 1000 μg/ml concentration both leaf and stem shows maximum radical scavenging activity (93 % & 98 %).

Superoxide anion scavenging assay also resulted promising activity with IC 50 values 85± 0.83μg/ml and 80± 0.90μg/ml respectively for leaf and stem. The percentage scavenging of super oxide radical surged with the enhanced concentration of plant extracts. The maximum scavenging activity of plant extract was at 1000 μg/ml concentration, 80 % and 92% respectively in leaf and stem extracts.

Preliminary phytochemical screening revealed the presence of saponins, steroids, flavonoids, terpenoids, cardiac glycosides and phenols in both stem and leaves that may be the reason for its biological properties.

Conclusion: The findings of this study indicate that this plant is medicinal with prominent antioxidant and anthelmintic property.

 

Keywords: White Abrus, Anthelmintic property, Anti-oxidant property, Phytochemistry, Traditional medicine.

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Author Biographies

Alby Alphons Baby, St. Mary's College, Thrissur, Kerala
Reseach Scholar Department of Botany St. May's College, Thrissur Kerala
Regi Raphael K, St. Mary's College, Thrissur, Kerala.
Head of the Dept. of Botany
St. Mary's College,
Thrissur, Kerala.

References

1. Kokate CB, Purohit AP, Gokhale SB. Pharmacognosy. 18 edition. Pune India: Nirali publication; 2002.
2. Essawi T, Srour M. Screening of some Palestinian medicinal plants for antibacterial activity. J Ethnopharmacol 2000;70:343-9.
3. .Kirikar KR, Basu BD. Indian Medicinal Plants Vol.1. Dehar Dun, India: International books Distributers; 1980.
4. Morton J F. Plants Poisonous to People in Florida and Other Warm Areas. Miami, Florida: Hallmark Press; 1982.
5. Manago CC, Alumanah EO. Antidiabetic effect chloroform-methanolextracts of Abrus precatorius seed. J Appl Sci Environ Mgt 2005;9:85–8.
6. Morton JF. Atlas of Medicinal Plants of Middle America: Bahamas to Yucatan. Springfield, Illinois: Charles C Thomas; 1981.
7. Irvine F R. Woody Plants of Ghana. London: Oxford University Press; 1961.
8. Anant Solanki, Maitreyi Zaveri. Pharmacognosy, phytochemistry and pharmacology of A. precatorius leaf: a review. Int J Pharm Sci Res 2012;13(2):71-6.
9. Gamble JS. Flora of presidency of Madras. Aldard and son publishing company ltd; 2004.
10. Taleb-Contini SH, Salvador MJ, Balanco JMF, Albuquerque S, De Oliveria DCR. Antiprotozoal effect of crude extracts and flavonoids isolated from Chromolaena hirsute (Asteraceae). Phyto Res 2004;18(3):250-4.
11. Harbone JB. Phytochemical methods, a guide to modern techniques of plant analysis. India: Springer pvt Hd; 1998.
12. Ajaiyeoba EO, Onocha PA, Olarenwaju OT. In vitro anthelmintic properties of B. coriaceae and G..gynandra extract. Pharm Biology 2001;39:217-20.
13. .Braca A, Sortino C, Politi M. Anti-oxidant activity of flavonoids from Licania licaniaeflora. J Ethnopharmacol 2002;79:379-81.
14. Bors W, Saran M, Elstner EF. Screening for plant anti-oxidants.In: Linskens HF, Jackson JF. eds. Modern Methods of Plant Analysis-Plant Toxin Analysis-New Series, Berlin: Springer.1992;13:277-95.
15. Bate Smith EC. The phenolic constituent of plants and their taxonomic significance, dicotylendons. J Linn Soc Bot 1962;58:95-103.
16. Andlauer W, Furst P. Antioxidative power of phytochemicals with special reference to cereals. Cereal Foods World 1998;43:356-9.
17. Jayaprakasha GK, Selvi T, Sakariah KK. Antibacterial and antioxidant activities of grape (Vitis vinifera) seed extract. Food Res Int 2003;36:117-22.
18. Shirwaikar A, Punitha ISR. Antioxidant studies on the methanol stem extract of Coscinium fenestratum. Nat Prod Sci 2007;13(1):40-5.
19. Aqil F, Ahmed I, Mehmood Z. Antioxidant and free radical scavenging properties of twelve traditionally used Indian medicinal plants: Turk J Biol 2006;30:177–8.
20. Cook NC, Samman S. Flavonoids-chemistry, metabolism, cardio-protective effects, and dietary sources. Nutritional effects and dietary sources. Nutr Biochem 1996;7:66–76.
21. Kessler M, Ubeaud G, Jung L. Anti-and prooxidant activity of rutin and quercetin derivatives. J Pharm Pharmacol 2003;55:131-42.
22. Shahidi F, Wanasundara PK. Phenolic antioxidants. Crit Rev Food Sci Nutr 1992;32:67-103.
23. Pourmorad F, Hosseinimehr SJ, Shahabimajd N. Antioxidant activity, phenol and flavonoid contents of some selected Iranian medicinal plants. African J Biotechnol 2006;5(11):1142-5.
24. Vinay R Patel, Prakash R Patel, Sushil S Kajal. Antioxidant activity of some selected medicinal plants in the Western Region of India. Adv Biol Res 2010;4(1):23-6.
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How to Cite
Baby, A. A., and R. R. K. “ANTIOXIDANT AND ANTHELMINTIC POTENTIAL OF THE STEM & LEAVES OF WHITE ABRUS”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 6, no. 10, 1, pp. 126-9, https://innovareacademics.in/journals/index.php/ijpps/article/view/2545.
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