ANTI-DIABETIC ACTIVITY OF HYDROALCOHOLIC EXTRACT OF EUGENIA JAMBOLANA LEAVES IN ALLOXAN INDUCED DIABETIC RATS

  • Shankar M Department of Pharmaceutical Chemistry, Seven Hills College of Pharmacy, Tirupati - 517561, Andhra Pradesh, India
  • R. Suthakaran Department of Pharmaceutical Chemistry and Regulatory Affairs, Teegala Ramreddy College of Pharmacy, Meerpet, Hyderabad - 500097, Andhra Pradesh, India

Abstract

Objective: The present study was carried out to evaluate the antidiabetic activity of hydroalcoholic extracts of Eugenia jambolana leaves.

Methods: The hydroalcoholic extracts of Eugenia jambolana by alloxan induced diabetic rats for 20 days. At high dose (400 mg/kg) it is exhibited significant anti- hyperglycaemic activity than hydroalcoholic extracts of Eugenia jambolana at low dose (200 mg/kg) in diabetic rats.

Results: The hydroalcoholic extracts of Eugenia jambolana also showed improvement in parameters like body weight, Serum Cholesterol level and hepatic glycogen as well as regeneration of beta-cells of pancreas in diabetic rats.

Conclusion: Histopathological studies reinforce the healing of kidney by hydroalcoholic extracts of Eugenia jambolana leaves as a possible mechanism of their antidiabetic activity. The present study provides a proof for the strong chemo taxonomical relationship for the plant

 

Keywords: Histopathological, Antidiabetic activity, Hydroalcohol and Eugenia jambolana leaves.

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Author Biography

Shankar M, Department of Pharmaceutical Chemistry, Seven Hills College of Pharmacy, Tirupati - 517561, Andhra Pradesh, India
PHARMACEUTICAL CHEMISTRY

References

1. Cooke DW, Plotnick L. Type 1 diabetes mellitus in pediatrics. Pediatr Rev 2008;29(11):374-84.
2. Cox DJ, Gonder Frederick LA, Clarke WL. Driving decrements in type 1 diabetes during moderate hypoglycemia. Diabetes J 1993;42(2):239-43.
3. Kumar GPS, Arulselvan P, Kumar DS, Subramanian SP. Anti-diabetic activity of fruits of Terminalia chebula on streptozotocin induced diabetic rats. J Health Sci 2006;52(3):283-91.
4. Sumana G, Suryawashi SA. Effect of vinca rosea extracts in treatenent of alloxan diabetes in male albino rats. Indian J Experimental Biol 2001;39:748-58.
5. Holman RR, Turner RC. Oral agents and insulin in the treatment of NIDDM in Text Book of Diabetes; 1991. p. 467-9.
6. OCED 425 guidelines. OCED Guidelines for testing animals 2001;26;1-26.
7. Kameswrarao B, Giri R, Kesavalu MM, Apparao CH. Herbal medicine in the Management by Indigenous Resources 1997;375-7.
8. Kameswara Rao B, Kesavulu MM, Apparao CH. Antihyperglycemic activity of Momordica cymbalaria in alloxan diabetic rats. J Ethnopharmacol 2001;78(1): 67-71.
9. Kannur DM, Hukkeri VI, Akki KS. Antidiabetic activity of Caesalpinia bonducella seeds extracts in rats. Fitoterapia 2006;77:546-9.
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How to Cite
M, S., and R. Suthakaran. “ANTI-DIABETIC ACTIVITY OF HYDROALCOHOLIC EXTRACT OF EUGENIA JAMBOLANA LEAVES IN ALLOXAN INDUCED DIABETIC RATS”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 6, no. 10, 1, pp. 138-40, https://innovareacademics.in/journals/index.php/ijpps/article/view/2580.
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