POTENTIAL CYTOTOXIC DRUG EFFECTS OF SECONDARY METABOLITES DERIVED FROM SELECTED MEDICINAL PLANTS OF SAVANADURGA FOREST IN KARNATAKA

  • Ashwatha Reddy Ravikumar Kuvempu University
  • Varun Madgaonkar PES Institute of Technology
  • Venkatesha Rampura Thirumalegowda Dayananda Sagar College of Biological Sciences
  • Bharathi R BMS Institute of Technology
  • V. Krishna Murthy PES Institute of Technology
  • R. T. Venkatesha Dayananda Sagar College of Biological Sciences

Abstract

Objective: To evaluate the potential cytotoxic and antitumor activities of secondary metabolites of selected medicinal plants of Savanadurga forest, Karnataka.

Methods: The soxhlet extracted crude methanolic leaf extracts of nineteen medicinal plants were assessed for their potential cytotoxic and antitumor activities by brine shrimp lethality assay and potato tumor inhibition assay at 100μg/ml respectively.

Results: Kirganelia reticulata and Cissus quadrangularis showed highest cytotoxicity while Flacourtia indica failed to show any inhibitory activity in brine shrimp lethality assay. Kirganelia reticulata exhibited 100% antitumor activity while Albizzia amara failed to show any antitumor activity as tested by crown gall tumor inhibition assay.

Conclusion: Both brine shrimp lethality assay and potato tumor inhibition assay indicated that Kirganelia reticulata seems to be the best anticancer plant.

 

Keywords: Brine Shrimp Lethality Assay, Potato Crown Gall Tumor Inhibition Assay, Kirganelia reticulata, Camptothecin, Catharanthus roseus, Withania somnifera, cytotoxicity.

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Ravikumar, A. R., V. Madgaonkar, V. R. Thirumalegowda, B. R, V. K. Murthy, and R. T. Venkatesha. “POTENTIAL CYTOTOXIC DRUG EFFECTS OF SECONDARY METABOLITES DERIVED FROM SELECTED MEDICINAL PLANTS OF SAVANADURGA FOREST IN KARNATAKA”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 6, no. 10, 1, pp. 238-41, https://innovareacademics.in/journals/index.php/ijpps/article/view/2607.
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