ANALGESIC EFFECT AND ANTI-INFLAMMATORY ACTIVITY OF AQUEOUS EXTRACT OF BOSWELLIA DALZIELII (BURSERACEAE) STEM BARK


Iyabo M., Adebisi ., Abba Abubakar, Kabiru Abubakar, Tijjani R., Giaze .

Abstract


Objective: To evaluate the analgesic effect and anti-inflammatory properties of Boswellia dalzielii (Burseraceae), a medicinal plant commonly used in northern Nigeria as an anti-diarrhoeal, antipyretic, analgesic and anti-inflammatory agent.

Methods: Three doses (25 mg/kg, 50 mg/kg and 100 mg/kg) of the crude aqueous extract of Boswellia dalzielii were evaluated for analgesic and anti-inflammatory activities using the acetic acid-induced writhing test, formalin-induced nociception and formalin-induced hind paw oedema in rats. The acute oral toxicity was carried out using the up and down procedure as described by the OECD guidelines.

Results: All doses (25, 50 and 100 mg/kg) of the extract tested were effective against acetic acid induced abdominal constrictions producing a percentage inhibition of (55.43, 69.56 and 71.73%) respectively. A percentage inhibition of the formalin-induced nociception of (7.31, 31.70 and 48.78%-early phase) and (12.82, 21.79 and 48.71%-late phase) respectively was also produced. For the acetic acid writhing test, the percentage inhibition obtained at the dose of 50 and 100 mg/kg (69.56 and 71.73%) were higher than that of the standard drug (Piroxicam, 10 mg/kg) (59.78%). For formalin-induced nociception, the test extract at 100 mg/kg showed a higher percentage inhibition compared to Piroxicam, in early (48.78 and 43.90%) and late phase (48.71 and 39.74 %) respectively. The extract, however, did not show a significant activity against formalin-induced paw oedema at all the doses used.

Conclusion: The present study demonstrated that Boswellia dalzielii has significant analgesic properties comparable to that of the standard drug (10% Piroxicam), thus validating the traditional claim of its antinociceptive property.


Keywords


Boswellia dalzielii, Analgesic, Anti-inflammatory

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About this article

Title

ANALGESIC EFFECT AND ANTI-INFLAMMATORY ACTIVITY OF AQUEOUS EXTRACT OF BOSWELLIA DALZIELII (BURSERACEAE) STEM BARK

Keywords

Boswellia dalzielii, Analgesic, Anti-inflammatory

DOI

10.22159/ijpps.2018v10i4.26156

Date

01-04-2018

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 10, Issue 4, 2018 Page: 139-142

Online ISSN

0975-1491

Authors & Affiliations

Iyabo M.
Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto
Nigeria

Adebisi .
Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto

Abba Abubakar
Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto

Kabiru Abubakar
Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto

Tijjani R.
Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto

Giaze .
Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto


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