VITAMIN-D DEFICIENCY AND RISK OF ACUTE CORONARY SYNDROME

  • Aya Hallak Department of Biochemistry and Microbiology, Faculty of Pharmacy, Aleppo University, Aleppo, Syria
  • Mahmoud Malhis Department of Cardiology, Aleppo University Hospital, Faculty of Medicine, Aleppo, Syria.
  • Mohammad Yaser Abajy Department of Biochemistry and Microbiology, Faculty of Pharmacy, Aleppo University, Aleppo, Syria.

Abstract

Objective: This study aimed to investigate the relation between vitamin D plasma concentrations and prevalence of prespecified coronary risk factors, and to assess the role of vitamin D deficiency as an independent risk factor for the acute coronary syndrome (ACS).

Methods: In this study, plasma 25-hydroxyvitamin D [25(OH)D] levels were measured in 60 consecutive ACS patients at hospital presentation, and patient data including socio-demographics and clinical variables were recorded at the time of admission. We used the Independent samples T-test and the chi-square test to compare differences in the continuous and categorical variables, respectively. The partial correlation coefficient was used to measure association between plasma vitamin D levels and acute coronary syndrome while controlling for traditional cardiovascular risk factors.

Results: This study found significant associations between low plasma vitamin D levels and prevalence of hypertension and smoking. Whereas, no significant association between low plasma vitamin D levels and prevalence of diabetes mellitus (DM) was found. There was a statistically significant correlation between vitamin D deficiency and acute coronary syndrome, even after controlling for traditional cardiovascular risk factors (P = 0.028).

Conclusion: Vitamin D deficiency is independently associated with acute coronary syndromes, and could be an independent risk factor for the acute coronary syndrome (ACS).

Keywords: Vitamin D deficiency, Cardiovascular risk factors, Acute coronary syndrome

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Hallak, A., M. Malhis, and M. Y. Abajy. “VITAMIN-D DEFICIENCY AND RISK OF ACUTE CORONARY SYNDROME”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 10, no. 6, June 2018, pp. 171-5, doi:10.22159/ijpps.2018v10i6.26469.
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