NEWER OPHTHALMIC IN SITU GEL OF MOXIFLOXACIN HYDROCHLORIDE: OPTIMIZATION USING BOX BEHNKEN STATISTICAL DESIGN


Mansi Dholakia, Richa Dave, Vaishali Thakkar, Hardik Rana, Mukesh Gohel, Nirav Patel

Abstract


Objective: The present research work aims at describing the formulation and evaluation of the ocular delivery system of moxifloxacin hydrochloride (MH) based on the concept of ion sensitive in situ gelations.

Methods: In situ gel was prepared by a hot method using 0.6% of gelrite, 0.25% hydroxypropylmethylcellulose (HPMC K4M) and 0.023% tamarind gum as bioadhesive polymers for sustained drug release. Optimization was done by Box Behnken Design with different concentration of gelrite (X1), HPMC K4M (X2) and tamarind gum (X3) as independent variables. In situ gel was optimized based on mucoadhesion index (Y1), Gel strength (Y2) and in vitro drug release (Y3). Influence of the quantitative variable on the dependent variable was predicted by a polynomial equation.

Results: Infrared spectroscopy excluded any interaction between drug and excipients. The selected independent variables significantly influenced the responses and were able to sustain the drug release. The prepared gel with a pH of 6.8 to 7.4 exhibited non-newtonian flow with no ocular irritation. The formulation remained stable with no change in pH and viscosity after 30 d of stability study.

Conclusion: Thus, moxifloxacin hydrochloride (MH) in situ gel is a viable alternative to a conventional delivery system with the properties of sustained drug release, prolonged ocular retention, and improved corneal penetration.


Keywords


Moxifloxacin hydrochloride (MH), Box-Behnken Design, Gelrite, HPMC K4M, Tamarind gum

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About this article

Title

NEWER OPHTHALMIC IN SITU GEL OF MOXIFLOXACIN HYDROCHLORIDE: OPTIMIZATION USING BOX BEHNKEN STATISTICAL DESIGN

Keywords

Moxifloxacin hydrochloride (MH), Box-Behnken Design, Gelrite, HPMC K4M, Tamarind gum

DOI

10.22159/ijpps.2018v10i12.26979

Date

01-12-2018

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 10, Issue 12, 2018 Page: 5-13

Online ISSN

0975-1491

Authors & Affiliations

Mansi Dholakia
Department of Pharmaceutics, Anand Pharmacy College, Anand, 388001, Gujarat, India
India

Richa Dave
Department of Pharmaceutics, Anand Pharmacy College, Anand, 388001, Gujarat, India
India

Vaishali Thakkar
Department of Pharmaceutics, Anand Pharmacy College, Anand, 388001, Gujarat, India
India

Hardik Rana
Department of Pharmaceutics, Anand Pharmacy College, Anand, 388001, Gujarat, India
India

Mukesh Gohel
Department of Pharmaceutics, Anand Pharmacy College, Anand, 388001, Gujarat, India
India

Nirav Patel
Department of Pharmaceutics, Anand Pharmacy College, Anand, 388001, Gujarat, India


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