FORMULATION AND EVALUATION OF MOISTURIZING CREAM CONTAINING SUNFLOWER WAX
Objective: The main objective of the present investigation was to design, prepare and evaluate moisturizing cream using sunflower wax.
Methods: In the present work 32 full factorial design was applied to study the effect of varying concentration of independent variables stearic acid (X1) and sunflower wax (X2) on dependent variables viscosity and spreadability. All of the prepared formulations of moisturizing cream were evaluated for its physicochemical parameters. Further, the optimized formulation and selected commercial moisturizer compared and evaluated for its physicochemical parameters like pH, particle size, spreadability, viscosity and in vitro occlusivity test.
Results: Nine different formulations of the moisturizing cream were prepared and all the findings obtained were within the prescribed limit. When compared to the prototype formulation of cream, the formulation MF5 showed good viscosity, in vitro occlusivity and spreadability. From the nine different formulations, MF5 containing 2 % stearic acid and 2 % sunflower was chosen as the optimized formula. Optimization was done on the basis of in vitro occlusivity studies and physicochemical parameters.
Conclusion: The results obtained in this research work clearly showed a promising potential of moisturizing cream containing a specific ratio of stearic acid and sunflower wax as emulsifiers. Thus it can be concluded that sunflower wax is incorporated in the moisturizing cream, to avail of its cosmetic benefits.
2. Marty JP. NMF and cosmetology of cutaneous hydration. Ann Dermatol Venereol 2002;129:131-6.
3. Cravellol B, Ferri A. Relationships between skin properties and environmental parameters. Skin Res Tech 2008;14:180-6.
4. Thorleifsson A, Wulf HC. Emollients and the response of facial skin to a cold environment. Br J Dermatol 2003;148:1149-52.
5. Egawa M, Oguri M, Kuwahara T. Effect of exposure of human skin to a dry environment. Skin Res Tech 2002;8:212-8.
6. Flynn TC, Petros J, Clark RE. Dry skin and moisturizers. Clin Dermatol 2001;19:387-92.
7. Yosipovitch G. Dry skin and impairment of barrier function associated with itch-new insights. Int J Cosm Sci 2004;26:1-7.
8. Loden M. Biophysical methods of providing objective documentation of the effects of moisturizing creams. Skin Res Technol 1995;1:101-8.
9. Awlings AVR, Anestrari DAC, Dobkowski B. Moisturizer technology versus clinical performance. Dermatol Ther 2004;17:49-6.
10. Kapoor S, Saraf S. Risk analysis tools for toxicological profile of cosmetics. Int J Toxicol 2008;5:1-20.
11. Paul Cancalon, Chemical composition of sunflower seed hulls. J Am Oil Chem Soc 1971;486:29-32.
12. Morrison WH. Variation in the wax content of sunflower seeds with location and hybrids. J Am Oil Chem Soc 1983;60:1013-5.
13. Ramos Ayerbe. A study on the recovery of byproducts from the dewaxing of sunflower oils of national production. Grasas Aceites 1985;36:1-4.
14. Wannee J. Review of nutraceutical uses of an antioxidant sunflower sprout. Asian J Pharm Clin Res 2016;9:21-3.
15. Mariani C. Minor components of vegetable oils: non-glyceridic esters. Riv Ital Sostanze Grasse 1989;66:397-401.
16. Amalia A Carelli. Wax composition of sunflower seed oils. J Am Oil Chem Soc 2002;79:763-8.
17. PP Sharma. Cosmetics-formulation, manufacturing and quality control, Cap. VII. 5th edition Vandana Publications, Delhi, India; 2014. p. 181-91.
18. Lachman L, Herbert AL, Joseph LK. The theory and practice of industrial pharmacy. Chp III. Varghese Publication House, India; 1999. p. 569.
19. Indian Standard Bureau IS: 6608; 1978. p. 5.1-6.1.
20. Indian Standard Bureau. Methods of testing for safety evaluation of cosÂ¬metic; 1997.
21. Julie MJ, Athira A, Verjina Cu, Vasudevan DT, Saritha AS. Formulation and evaluation of antiaging phytosomal gel. Asian J Pharm Clin Res 2018;11:409-22.
22. Mandawgade SD, Patravale VB. Development of SLNs from natural lipids: application to topical delivery of tretinoin. Int J Pharm 2008;363:132-8.
23. Rowe RC, Sheskey PJ, Weller PJ. Handbook of pharmaceutical excipients. London: Pharmaceutical Press; 2003.
24. Dua D, Srivastava NS. Study on antioxidant and anti-aging properties of few medicinal plants. Int J Pharm Pharm Sci 2016;8:344-7.
25. Taylor P. Ostwald ripening in emulsions. Adv Colloid Interface Sci 1998;75:107-63.
26. Baird. Analysis of creams and lotions. In: Henry MD. editor. Manual of cosmetic analysis. USA; 1997. p. 32-3.
27. Clarke MT. Rheological additives. In: Laba D. editor. Rheological properties of cosmetic and toiletries. New York: Marcel Dekker; 1993. p. 55-152.
28. Multimer M. Spreadability determination by an apparatus. J Am Pharm Assoc 1956;45:212-4.