SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL STUDY OF SOME BENZENESULFONAMIDE BASED BIPYRAZOLES

  • Karan Singh Eternal University, Baru Sahib
  • Pawan K Sharma Department of Chemistry Kurukshetra Unviersity Kurukshetra-136119, INDIA

Abstract

Objectives: To synthesize, characterize and evaluate antimicrobial properties of some benzenesulfonamide based bipyrazole.

Methods: The benzenesulfonamide based bipyrazole 1a-d & 2a-f have been synthesized by the reaction between 1-[1-aryl / (benzothiazol-2-yl)-5-hydroxy-3-methylpyrazol-4-yl]butane-1,3-diones 5 and 2-hydrazinobenzothiazoles or Aryl hydrazines 3. The structures of these compounds have been characterized from the rigorous analysis of their IR, 1H-NMR, HRMS and elemental analysis. These compounds were screened for their anti-microbial activity.

Results: The results revealed that compounds 1a, 2b and 2f exhibited good antibacterial activity and 1b, 1c, 2a, and 2d showed moderate antibacterial activity as compared with standard drug Ofloxacin.

Conclusion: This study provides the simple method for the synthesis of new benzenzenesulfonamide based bipyrazoles which plays important role in numerous bioactive compounds.

 

Keywords: Bipyrazole, Butane-1, 3-diones, 2-Hydrazinobenzothiazoles, Arylhydrazines, Benzenesulfonamide, Anti-microbial.

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Author Biographies

Karan Singh, Eternal University, Baru Sahib
Associate Professor; Akal School of Chemistry
Pawan K Sharma, Department of Chemistry Kurukshetra Unviersity Kurukshetra-136119, INDIA

 Professor; Department of Chemistry

Kurukshetra Unviersity

Kurukshetra-136119, INDIA

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How to Cite
Singh, K., and P. K. Sharma. “SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL STUDY OF SOME BENZENESULFONAMIDE BASED BIPYRAZOLES”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 6, no. 10, 1, pp. 345-51, https://innovareacademics.in/journals/index.php/ijpps/article/view/2888.
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