CONVENTIONAL AND ADVANCED DIAGNOSTIC AIDS IN ORAL CANCER SCREENING â€“ THE JOURNEY SO FAR
Oral cancer accounts for a significantly higher percentage of all cancer cases. Survival rates of oral cancers are relatively low in comparison to other major cancers, although incidence rates are as low as 3%. Oral cancer is the most common cancer among Indian males and third most common cancer among Indian females. Delay in diagnosis, metastases, and the presence of secondary tumors are the major reasons for the poor prognosis of oral cancers. Innocuous potentially malignant lesions have higher chances for malignant transformation and early diagnosis of these lesions is necessary for improving survival rates. The patient's overall outcome can be enhanced through early diagnosis and management of these potentially malignant lesions, as the risk factors are well documented for oral cancers. Currently available clinical diagnostic tools developed for the early detection of oral cancers includes toluidine blue dye (TB) (tolonium chloride), Oral brush biopsy, chemiluminescence using Vizilite, salivary diagnostics, and several imaging devices such as Velscope and multispectral optical imaging systems. This paper provides a detailed review about the various diagnostic aids in the detection of oral cancers and also emphasizes a dentist's role in combating this dreadful entity.
2. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics. Ca-Cancer J Clin 2009;59(4):225-49.
3. Parkin DM, Laara E, Muir CS. Estimates of the worldwide frequency of sixteen major cancers in. Int J Cancer 1988;41(2):184-97.
4. Matsuda T, Marugame T, Kamo KI, Katanoda K, Ajiki W, Sobue T. Cancer incidence and incidence rates in Japan in 2003: based on data from 13 population-based cancer registries in the monitoring of cancer incidence in Japan (MCIJ) project. Jpn J Clin Oncol 2009;39(12):850-8.
5. Schantz SP, Yu GP. Head and neck cancer incidence trends in young Americans, 1973-1997, with a special analysis for tongue cancer. Arch Otolaryngol Head Neck Surg 2002;128(3):268-74.
6. Mork J, Lie AK. Human papillomavirus infection as a risk factor for squamous cell carcinoma of the head and neck. N Engl J Med 2001;344(15):1125-31.
7. American Cancer Society, California Division and Public Health Institute, California Cancer Registry. California Cancer Facts and fig. 2007. Oakland, American Cancer Society, California Division, September; 2006.
8. Epstein JB, Silverman S Jr. Analysis of oral lesion biopsies identified and evaluated by visual examination, chemiluminescence and toluidine blue. Oral Oncol 2008;44;538-44.
9. Wong DT. Toward a simple, saliva-based test for the detection of oral cancer. Expert Rev Mol Diagn 2006;6(3):267-72.
10. Lingen MW, Kalmar JR. Critical evaluation of diagnostic aids for the detection of oral cancer. Oral Oncol 2008;44:10-22.
11. Trullenque-Eriksson A, MuÃ±oz-Corcuera M. Analysis of new diagnostic methods in suspicious lesions of the oral mucosa. Med Oral Patol Oral Cir Bucal 2009;14(5):210-6.
12. Patton LP, Epstein JB, Kerr RA. Adjunctive techniques for oral cancer examination and lesion diagnosis: a systematic review of the literature. J Am Dent Assoc 2008;139;896-905.
13. Nakanishi Y, Ochiai A, Yoshimura K, Kato H, Shimoda T, Yamaguchi H, et al. The clinicopathological significance of small areas unstained by Lugolâ€²s iodine in the mucosa surrounding resected esophageal carcinoma-An analysis of 147 cases. Cancer 1998;82;1454-9.
14. Epstein JB, Scully C, Spinelli J. Toluidine blue and lugolâ€²s iodine application in the assessment of oral malignant disease and lesions at risk of malignancy. J Oral Pathol Med 1992;21:160-63.
15. Nakanishi Y, Ochiai A, Shimoda T, Yamaguchi H, Tachimori Y, Kato H, et al. Epidermization in the oesophageal mucosa: unusual epithelial changes clearly detected by lugolâ€²s staining. Am J Surg Pathol 1997;21:605-09.
16. Isacsson G, Shear M. Content and distribution of glycogen in oral epithelial dysplasia. Scand J Dent Res 1981;89:79-88.
17. Nagaraju K, Prasad S, Ashok L. Diagnostic efficiency of toluidine blue with Lugol's iodine in oral premalignant and malignant lesions. Indian J Dent Res 2010;2:218-23.
18. Masthan KMK, Babu Aravindha N, Dash Chandra Kailash, Elumala M. Advanced diagnostic aids in oral cancer. Asian Pac J Cancer Prev 2012;13:3573-6.
19. Christian DC. Computer-assisted analysis of oral brush biopsies at an oral cancer screening program. J Am Dent Assoc 2002;133:357-62.
20. Scheifele C, Schmidt-Westhausen AM, Dietrich T, Reichart PA. The sensitivity and specificity of the Oral CDx technique: evaluation of 103 cases. Oral Oncol 2004;40:824-8.
21. Eisen D, Frist S. The relevance of the high positive predictive value of the oral brush biopsy. Oral Oncol 2005;41:753-5.
22. Bench MK. Oral brush biopsies. J Am Dent Assoc 2006;137:294.
23. Carlson R, Lewis SW, Lim KF. Seeing the light: using chemiluminescence to demonstrate chemical fundamentals. Aust J Chem Ed 2000;14:51-3.
24. Oh ES, Laskin DM. Efficacy of the ViziLite system in the identification of oral lesions. J Oral Maxillofacial Surg 2007;65:424-26.
25. Ram S, Siar CH. Chemiluminescence as a diagnostic aid in the detection of oral cancer and potentially malignant epithelial lesions. Int J Oral Maxillofac Surg 2005;34:521-7.
26. Farah CS, McCullough MJ. A pilot case control study on the efficacy of acetic acid wash and chemiluminescent illumination (ViziLite) in the visualisation of oral mucosal white lesions. Oral Oncol 2007;43:820-4.
27. Epstein JB, Gorsky M, Lonky S, Silverman S Jr, Epstein JD, Bride M. The efficacy of oral lumenoscopy (ViziLite) in visualizing oral mucosal lesions. Spec Care Dentist 2006;26:171-4.
28. Rosin MP, Poh CF. Visualization and other emerging technologies as change makers for oral cancer prevention. Ann N Y Acad Sci 2007;1098:167-83.
29. De Veld DC, Witjes MJ, Sterenborg HJ, Roodenburg JL. The status of in vivo auto fluorescence spectroscopy and imaging for oral oncology. Oral Oncol 2005;41:117-31.
30. Nagler RM. Saliva as a tool for oral cancer diagnosis and prognosis. Oral Oncol 2009;45:1006-10.
31. Bahar G, Feinmesser R, Popovtzer A, Nagler RM. Salivary analysis in oral cancer patients: DNA and protein oxidation, reactive nitrogen species, and antioxidant profile. Cancer 2007;109(1):54-9.
32. Li Y, St John MA, Zhou X, Kim Y, Sinha U, Jordan RC, et al. Salivary transcriptome diagnostics for oral cancer detection. Clin Cancer Res 2004;10:8442-50.
33. Kim CS, Wilder-Smith P, Ahn YC, Liaw LH, Chen Z, Kwon YJ. Enhanced detection of early-stage oral cancer in vivo by optical coherence tomography using multimodal delivery of gold nanoparticles. J Biomed Opt 2009;14(3);034008
34. Wilder-Smith P, Woong-Gyu Jung. In vivo optical coherence tomography for the diagnosis of oral malignancy. Lasers Surg Med 2004;35(4):269-75.
35. Wilder-Smith P, Krasieva T. Noninvasive imaging of oral pre-malignancy and malignancy. J Biomed Opt 2005;10(5):51601.
36. Kawakami-Wong H, Hammer-Wilson MJ. In vivo optical coherence tomography-based scoring of oral mucositis in human subjects: a pilot study. J Biomed Opt 2007;12(5):051702.
37. Bradley G, Odell EW, Raphael S, Ho J, Le LW, Benchimol S, et al. Abnormal DNA content in oral epithelial dysplasia is associated with increased risk of progression to carcinoma. Br J Cancer 2010;103(9):1432-42.
38. Fischer DJ, Epstein JB, Morton TH Jr, Schwartz SM. Reliability of histologic diagnosis of clinically normal intraoral tissue adjacent to clinically suspicious lesions in former upper aero digestive tract cancer patients. Oral Oncol 2010;41(5):489-96.
39. Fischer DJ, Epstein JB, Morton TH, Schwartz SM. Interobserver reliability in the histopathologic diagnosis of oral pre-malignant and malignant lesions. J Oral Pathol Med 2004;33(2):65-70.
40. Thomson PJ. Field change and oral cancer: new evidence for widespread carcinogenesis? Int J Oral Maxillofac Surg 2002;31(3):262-6.