• Karina Ivonne Fuentes-gonzÁlez Department of Pharmacy, National School of Biological Sciences, National Polytechnic Institute of Mexico, D. F. Mexico, Unidad Profesional Adolfo López Mateos. Col. Industrial Vallejo, C. P. 07738, D. F. México.
  • Leopoldo Villafuerte-robles Department of Pharmacy, National School of Biological Sciences, National Polytechnic Institute of Mexico, D. F. Mexico, Unidad Profesional Adolfo López Mateos. Col. Industrial Vallejo, C. P. 07738, D. F. México.


Objective: The purpose of the work was the assessment of the GalenIQ 720 flowability as a functionality parameter of the excipient, comparing two different methods.

Methods: The evaluated parameters were the powder flow through different size orifices and the compressibility index, as absolute values and as values relative to Helmcel 200. The parameters determined with pure excipients and in mixtures with a model drug, metronidazole.

 Results: The compressibility index is a specific measurement for each powders blend that allows the assessment of its overall flow properties. Flowability, expressed as the flow rate, shows so many different results as orifices are being tested. Both methods exhibit comparable results only by wide orifice sizes where the interaction with de orifice walls is minimized. The flow rate increases progressively, mostly in a potential relationship, with an increasing orifice diameter. The flow rate of GalenIQ 720 attains a maximum with 0.4-0.8% magnesium stearate. Formulations containing GalenIQ 720 show about 2.8 times greater flowability than those containing Helmcel 200 while the flowability of GalenIQ 720 is about 8.7 times greater than that of Helmcel. The presence of metronidazole attenuates the differences observed by the flowability of pure excipients and its spread.

Conclusion: Both methods consistently show a comparable improvement of metronidazole flowability with GalenIQ 720 and a deterioration of the same with Helmcel 200. The knowledge of the individual materials flowability allows the inference of their effect on the flowability of their mixtures but not the magnitude of this effect.


Keywords: Powder flow, Compressibility index, Surrogate functionality, Explicit functionality, Relative functionality, Metronidazole, Lubricants.


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1. Navaneethan CC, Missaghi S, Fassih R. Application of powder rheometer to determine powder flow properties and lubrication efficiency of pharmaceutical particulate systems. AAPS Pharm Sci Tech 2005;6(3):E398-404.
2. Liu L, Marziano I, Bentham A, Litster J, White E, Howes T. Effect of particle properties on the flow ability of ibuprofen powders. Int J Pharm 2008;362:109-17.
3. Klevan I, Nordström J, Tho I, Alderborn G. A statistical approach to evaluate the potential use of compression parameters for classification of pharmaceutical powder materials. Eur J Pharm Biopharm 2010;75:425–35.
4. Jallo L, Ghoroi C, Gurumurthy L, Patel U, Davé R. Improvement of flow and bulk density of pharmaceutical powders using surface modification. Int J Pharm 2012;423:213-25.
5. Sarraguca M, Cruz A, Soares S, Amaral H, Costa P, Lopes J. Determination of flow properties of pharmaceutical powders by near infrared spectroscopy. J Pharm Biomed Anal 2010;52:484-92.
6. Hancock BC. Achieving a perfect tablet formulation: evolution, or intelligent design? Am Pharm Rev 2009:12(2).
7. Moreton R. Ch functionality and performance of excipients. Pharm Tech 2006. http: //pharmtech. findpharma. com/ pharmtech/Excipients/Functionalityand-Performance-of-Excipients/ArticleStandard/Article/detail/378395.
8. Villafuerte L. The excipients and their functionality in pharmaceutical solid products. Rev Mex Cienc Farm 2011;42:18-36.
9. Freeman T. Implementing QbD: powder characterization for design space definition. Freeman Technology 2009. http: //www. freemantech. co. uk/es/descarga-de-documentos/articulos-y-libros-blancos. html.
10. Suñé-Negre J, Pérez P, Roig M, Fuster R, Hernández C, Ruhí R, et al. Optimization of parameters of the se de m diagram expert system: hausner index (ih) and relative humidity (%RH). Eur J Pharm Biopharm 2011;79:464-72.
11. Mohammed S, Adbullah E, Geldart D, Raman A. Measuring powder flowability with a modified warren spring cohesion tester. Particuology 2011;9:148-54.
12. Shah R, Tawakkul M, Khan M. Comparative evaluation of flow for pharmaceutical powders and granules. AAPS Pharm Sci Tech 2008;9:250-8.
13. Fu X, Huck D, Makein L, Armstrong B, Willen U, Freeman T. Effect of particle shape and size on flow properties of lactose powders. Particuology 2012;10:203-8.
14. Faqih A, Alexander A, Muzzio F, Tomassone M. A method for predicting hopper flow characteristics of pharmaceutical powders. Chem Eng Sci 2007;62:1536-42.
15. Faqih A, Mehrotra A, Hammond S, Muzzio F. Effect of moisture and magnesium stearate concentration on flow properties of cohesive granular materials. Int J Pharm 2007b; 336:338-45.
16. Chi-Ying A. Use of angle of repose and bulk densities for powder characterization and the prediction of minimum fluidization and minimum bubbling velocities. Chem Eng Sci 2002;57(14):2635-40.
17. Ganesan V, Rosentrater K, Muthukumarappan K. Flowability and handling characteristics of bulk solids and powders a review with implications for DDGS. Biosys Eng 2009;101(4):425-35.
18. Rios M. Developments in powder flow testing. A harmonized USP chapter and sophisticated measuring systems are small steps toward understanding powder flowability. Pharm Tech 2006. http: //www. pharmtech. com/pharmtech/ article/articleDetail. jsp?id=301457.
19. Why measure the flow properties of powders? Stable Micro Systems Ltd. http://www.stablemicrosystems.com.cn/ powwhy. htm. 2012.
20. GalenIQ 720. http: //www. higuchi-inc. co. jp/pharma/ excipient/isomalt/pdf/detail_galenIQ720.pdf.2012.
21. Ndindayino F, Henrist D, Kiekens F, Van den Mooter G, Vervaet C, Remon JP. Direct compression properties of melt extruded isomalt. Int J Pharm 2002;235:149–57.
22. Seppälä K, Heinämäki J, Hatara H, Seppälä L, Yliruusi J. Development of a new method to get a reliable powder flow characteristics using only 1 to 2 g of powder. AAPS Pharm Sci Tech 2010;11(1):402–8.
23. GalenIQ™ – The smart excipient. PALATINIT GmbH. Germany. http://abstracts.aapspharmaceutica.com/expoaaps07/Data/EC/Event/Exhibitors/365/4f7c678c-0e96-4a5f-8684-28c2cf5ec022. pdf. 2012.
24. Chawla M, Srinivasan G. Evaluation of galeniq polymer in tramadol hydrochloride orally disintegrating tablet. Int J Drug Deliv 2011;3:439-55.
25. Yokohama S, Yoneda M, Haneda M, Okamoto S, Okada M, Aso K, et al. Therapeutic efficacy of an angiotensin II receptor antagonist in patients with nonalcoholic steatohepatitis. Hepatology 2004;40(5):1222-5.
26. Sun Ch C. Setting the bar for powder flow properties in successful high speed tableting. Pow Tech 2010;201:106–8.
27. Freeman R. Assessing powder stability. Freeman Technology, White Papers, article 10. http://www. freemantech.co.uk/ en/literature-and-downloads/articles-and-white-papers. html. 2013.
28. Villafuerte L. Mezclado de sólidos. Productos Farmacéuticos Sólidos: Operaciones Unitarias Farmacéuticas. México: Instituto Politécnico Nacional; 1999. p. 96-111.
29. Hou H, Sun C. Effect of magnesium stearate on powder flow properties. AAPS 2007, 001075. http: //www. aapsj.org/ abstracts/AM_2007/AAPS2007-001075. PDF. 2012.
30. Morin G J. The effects of lubrication on pharmaceutical granules. A thesis submitted in partial fulfillment of the requirements for the degree of Master of Engineering Science. School of Graduate and Postdoctoral Studies, University of Western Ontario. London, Ontario, Canada. Reviewed by Lauren Briens; 2012.
31. Odeniyi M A, Onyenaka C Ch, Itiola OA. Powder properties of binary mixtures of chloroquine phosphate with lactose and dicalcium phosphate. Braz J Pharm Sci 2010;46(3):531-7.
32. Soppela I, Airaksinen S, Murtomaa M, Tenho M, Hatara J, Räikkönen H, et al. Investigation of the powder flow behaviour of binary mixtures of microcrystalline celluloses and paracetamol. J Excip Food Chem 2010;1(1):55-67.
33. Rao Nalluri V, Puchkov M, Küntz M. Toward better understanding of powder avalanching and shear cell parameters of drug–excipient blends to design minimal weight variability into pharmaceutical capsules. Int J Pharm 2013;442(1–2):49-56.
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How to Cite
Fuentes-gonzÁlezK. I., and L. Villafuerte-robles. “POWDER FLOWABILITY AS A FUNCTIONALITY PARAMETER OF THE EXCIPIENT GALENIQ 720”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 6, no. 9, 1, pp. 66-74, https://innovareacademics.in/journals/index.php/ijpps/article/view/3201.
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