• Sheik Mohideen Sahabudeen Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology https://orcid.org/0000-0002-9921-8039
  • Hindol Nag Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology https://orcid.org/0000-0001-8274-8108
  • Suneeti Madhavan Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology
  • Abhinav Chatterjee Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology
  • Pallavi Dan Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology https://orcid.org/0000-0002-5814-2912
  • Mahasweta Bhattacharya Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology
  • Zail Ali Nawaz Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology


Objective: Andrographis paniculata is widely used in Asia for various medicinal purposes. The plant has a major bioactive chemical constituent Andrographolide, which exhibits various essential pharmacological properties. Recently, to enhance immunity against viral fevers especially dengue viral fever during monsoon season, Tamil Nadu state government has advised rural health centres to provide a tea or kashayam made from a mixture containing this plant leaf along with selected plant roots and leaves. However, there is concern among the general public population that this plant extract may have a negative impact on potency. This study is being done to investigate the toxic effects of Andrographis paniculata on fecundity and physiological properties of Drosophila melanogaster.

Methods: The flies were treated and mated in pure and mixed form of Andrographis paniculata separately.

Results: The results were obtained in the form of egg count, which was compared to control and the conclusion was obtained that Andrographis paniculata might affect the fecundity and at the same time, it was observed that the developmental span from an egg to an adult fly increased upon treatment in successive generations. More importantly, the effect of pure form plant on the fecundity was found to be significant, while that of the mixed form was not. On mating a treated male with an untreated female and an untreated male with a treated female when the treatment is being discontinued, it can be very well seen that there is no effect on the fecundity of the flies.

Conclusion: Since the continuity of the treatment played a major role on the effect of fecundity, highlighting the importance of the period of treatment and the exposure time of the compound on the fly system, therefore this research suggests that the conception of tea or kashayam extracted from mixed plant content could not have the same effect as the similar concentration of pure Andrographis paniculata and it does not have any acute effect on the fecundity when being consumed over a short period of time in Drosophila melanogaster model.

Keywords: Andrographolide, Acute effect, Continuity, Developmental span, Fecundity, Nilevembu


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How to Cite
Sahabudeen, S. M., H. Nag, S. Madhavan, A. Chatterjee, P. Dan, M. Bhattacharya, and Z. A. Nawaz. “FECUNDITY STUDIES OF ANDROGRAPHIS PANICULATA ON DROSOPHILA MELANOGASTER”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 11, no. 6, June 2019, pp. 23-27, doi:10.22159/ijpps.2019v11i6.32093.
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