1,3,4-THIADIAZOLE: A BIOLOGICALLY ACTIVE SCAFFOLD


Habibullah Khalilullah, M U Khan, Danish Mhmood, Jawed Akhtar, Gamal Osman

Abstract


There has been considerable interest in the development of novel compounds with anticonvulsant, antidepressant, analgesic, anti-inflammatory, anti allergic, antipsychotic, antimicrobial, antimycobecterial, antitumour, antiviral and antitubercular activities. 1,3,4-thiadiazole constitute an important class of compound for new drug development. They have interesting pharmacophore that display a broad spectrum of biological activity. The 1,3,4-thiadiazole scaffold is an interesting building block that has been used to synthesize a variety of useful bioactive compounds. The stability of thiadiazole nucleus has inspired medicinal chemist to carry out various structural variation in the ring. The marketed drugs such as acetazolamide, methazolamide, globucid proved their therapeutic potential Therefore; many researchers have synthesized these compounds as target structures and evaluated their biological activities. These observations have been instrumental in the development of new 1,3,4-thiadiazole derivatives. This review highlights the various biological activities associated with 1,3,4-thiadiazole ring system.


 


Keywords


1,3,4-Thiadiazole, Thiadiazole, Azole.

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About this article

Title

1,3,4-THIADIAZOLE: A BIOLOGICALLY ACTIVE SCAFFOLD

Keywords

1,3,4-Thiadiazole, Thiadiazole, Azole.

Date

01-10-2014

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 6, Issue 9, 2014 Page: 8-15

Online ISSN

0975-1491

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521 Views | 277 Downloads

Authors & Affiliations

Habibullah Khalilullah
Department of Pharmaceutics and Pharmaceutical Chemistry, Unaizah College of Pharmacy, Qassim University, Kingdom of Saudi Arabia
Saudi Arabia

M U Khan
Department of Pharmaceutics and Pharmaceutical Chemistry, Unaizah College of Pharmacy, Qassim University, Kingdom of Saudi Arabia
Saudi Arabia

Danish Mhmood
Department of Pharmacology, Unaizah College of Pharmacy, Qassim University, Kingdom of Saudi Arabia
Saudi Arabia

Jawed Akhtar
Department of Pharmaceutics and Pharmaceutical Chemistry, Unaizah College of Pharmacy, Qassim University, Kingdom of Saudi Arabia
Saudi Arabia

Gamal Osman
Department of Pharmaceutics and Pharmaceutical Chemistry, Unaizah College of Pharmacy, Qassim University, Kingdom of Saudi Arabia
Saudi Arabia


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