• Habibullah Khalilullah Department of Pharmaceutics and Pharmaceutical Chemistry, Unaizah College of Pharmacy, Qassim University, Kingdom of Saudi Arabia
  • M. U. Khan Department of Pharmaceutics and Pharmaceutical Chemistry, Unaizah College of Pharmacy, Qassim University, Kingdom of Saudi Arabia
  • Danish Mhmood Department of Pharmacology, Unaizah College of Pharmacy, Qassim University, Kingdom of Saudi Arabia
  • Jawed Akhtar Department of Pharmaceutics and Pharmaceutical Chemistry, Unaizah College of Pharmacy, Qassim University, Kingdom of Saudi Arabia
  • Gamal Osman Department of Pharmaceutics and Pharmaceutical Chemistry, Unaizah College of Pharmacy, Qassim University, Kingdom of Saudi Arabia


There has been considerable interest in the development of novel compounds with anticonvulsant, antidepressant, analgesic, anti-inflammatory, anti allergic, antipsychotic, antimicrobial, antimycobecterial, antitumour, antiviral and antitubercular activities. 1,3,4-thiadiazole constitute an important class of compound for new drug development. They have interesting pharmacophore that display a broad spectrum of biological activity. The 1,3,4-thiadiazole scaffold is an interesting building block that has been used to synthesize a variety of useful bioactive compounds. The stability of thiadiazole nucleus has inspired medicinal chemist to carry out various structural variation in the ring. The marketed drugs such as acetazolamide, methazolamide, globucid proved their therapeutic potential Therefore; many researchers have synthesized these compounds as target structures and evaluated their biological activities. These observations have been instrumental in the development of new 1,3,4-thiadiazole derivatives. This review highlights the various biological activities associated with 1,3,4-thiadiazole ring system.

Keywords: 1,3,4-Thiadiazole, Thiadiazole, Azole


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How to Cite
Khalilullah, H., M. U. Khan, D. Mhmood, J. Akhtar, and G. Osman. “1,3,4-THIADIAZOLE: A BIOLOGICALLY ACTIVE SCAFFOLD”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 6, no. 9, 1, pp. 8-15, https://innovareacademics.in/journals/index.php/ijpps/article/view/3212.
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