FORMULATION AND EVALUATION OF FAMOTIDINE FAST DISSOLVING TABLETS USING SYNTHETIC SUPERDISINTEGRANTS

  • SARIPILLI RAJESWARI Affiliated to Andhra University, Maharajah’s College of Pharmacy, Phool Baugh, Vizainagaram 535002, India
  • M. YERNI KUMARI Affiliated to Andhra University, Maharajah’s College of Pharmacy, Phool Baugh, Vizainagaram 535002, India

Abstract

Objective: The main aim of the present research work was to formulate fast dissolving tablets of famotidine by direct compression method and to evaluate the effect of synthetic super disintegrating agent on drug release pattern.


Methods: The fast dissolving tablets were prepared by using crospovidone, croscarmellose sodium, sodium starch glycolate as superdisintegrants (2, 4 and 6 %w/w), mannitol 20 % and microcrystalline cellulose (44, 46 and 48 % w/w) as a directly compressible vehicle. All the prepared tablets were evaluated for hardness, friability, drug content uniformity, weight variation, disintegrating time, wetting time and in vitro drug release studies.


Results: All the prepared fast dissolving tablets formulations were within the Pharmacopoeial standards limits. Based on in vitro drug release studies (>90 % within 30 min), the optimised formulations were optimised tested for the short term stability (at 40 ˚C/75% RH for 3 mo) and drug excipient interaction (fourier transform infrared spectroscopy).


Conclusion: Hence, formulation prepared with 6 % w/w of crosspovidine and 44 % w/w of microcrystalline cellulose as emerged as the overall best formulation (>90 % within 30 min) compared to marketed product (>70 % within 30 min). Short-term stability studies on the formulations indicated that there are no significant changes in drug content and in vitro drug release (p<0.05).

Keywords: Famotidine, Croscarmellose sodium, Crosspovidine, Sodium starch Glycolate, Fast dissolving tablets

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References

1. Sutpute MM, Shivaji NT. Formulation and in vitro evaluation of fast dissolving tablets of metoprolol tartrate. Braz J Pharm Sci 2013;49:783-92.
2. Famotidine drug profile. Available from: https:// www.drugbank.ca/drugs/DB00927 [Last accessed on 15 Nov 2017].
3. Famotidine drug details. Available from: https:// www.fda.gov/Drugs/InformationOnDrugs/ucm129662.htm. [Last Accessed on 21 Apr 2018]
4. Famotidine drug profile. Available from: https:// pubchem.ncbi.nlm.nih.gov/compound/famotidine#section=Information-Sources. [Last accessed on 16 Nov 2017]
5. Rose RSS, Shanmuganathan TRS, Senthil KSR, Thanga TA. Formulation and evaluation of mouth dissolving famotidine tablet. Int J Chem Tech Res 2009;1:1251-6.
6. Venkateswarlu B, Pragati BK, Debjit B. Formulation and evaluation of famotidine fast dissolving tablets by direct compression method. Indian J Res Pharm Biotechnol 2013;1:609-13.
7. Rajeswari S, Sravya K, Murthy KVR. Development, formulation and evaluation of a bilayer gastric retentive floating tablets of ranitidine HCl and clarithromycin using natural polymers. Int J Pharm Pharm Sci 2017;9:164-77.
8. Vijayanand P, Sridevi P, Bhagavan Raju M. Development and optimization of orodispersible tablets of carvedilol by a combination of super-disintegrants addition and sublimation techniques. Int J Pharm Pharm Sci 2017;9:155-60.
9. Hari K, Rajeswari S, Murthy KVR. Preparation and evaluation of orally disintegrating tablets of drotaverine hydrochloride using sublimation technique. Int J Pharm Pharm Sci 2018;10:85-95.
10. Shah U, Augsburger L. Evaluation of the functional equivance of crospovidone NF from different sources: standard performance test. Pharm Dev Technol 2001;6:419-30.
11. Bhaskaran S, Narmada GV. Orally disintegrating tablets. Indian Pharm 2002;1:9-12.
12. Kaushik D, Dureja H, Saini TR. Mouth dissolving tablets: a review. Indian Drugs 2004;41:187-93.
13. Mishra B, Panigrahi D. Mouth dissolving tablets: an overview of preparation techniques, evaluation and patented technologies. J Pham Res 2005;4:33.
14. Jhansi Rani M, Surendra A, Sudhakar AM, Nagoor A. Formulation and evaluation of domperidone fast dissolving tablets using natural superdisintegrants. Int J Res Pharm Nano Sci 2013;2:152-7.
15. Parmar RB, Baria AH, Tank HM. Formulation and evaluation of domperidone fast dissolving tablets. Int J Pharm Tech Res 2009;1:483-7.
16. Subrahmanyam CVS. Text book of physical pharmaceutics. 2nd Ed. New Delhi: Vallabh Prakashan; 2005. p. 210-28.
17. Lachman L, Lieberman A, Kinig JL. The theory and practice of industrial pharmacy. 2nd ed. Varghese Publishing House; 1999. p. 67-74.
18. Govt. of India, Ministry of health and family welfare. Indian pharmacopoeia 2007. The Indian pharmacopoeia commission, Ghaziabad; 2007;1:177-87.
19. Padmaja B, Ramakrishna R, Goutham G. Formulation and evaluation of fast dissolving tablets of ranitidine hydrochloride. J Pharm Res 2015;9:165-9.
20. Anupama K, Shelly K, Neena B. Formulation and evaluation of mouth dissolving tablets of oxcarbazepine. Int J Pharm Pharm Sci 2009;1:12-23.
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RAJESWARI, S., and M. Y. KUMARI. “FORMULATION AND EVALUATION OF FAMOTIDINE FAST DISSOLVING TABLETS USING SYNTHETIC SUPERDISINTEGRANTS”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 11, no. 8, June 2019, pp. 17-25, doi:10.22159/ijpps.2019v11i8.33175.
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