• Kaloyan Georgiev Department of Pharmaceutical technologies, Faculty of Pharmacy, Medical University of Varna, Bulgaria
  • Nadezhda Hvarchanova Department of Pharmacology, toxicology and pharmacotherapy, Faculty of Pharmacy, Medical University of Varna, Bulgaria
  • Marieta Georgieva Department of Pharmacology, toxicology and pharmacotherapy, Faculty of Pharmacy, Medical University of Varna, Bulgaria
  • Branimir Kanazirev Department of Internal Medicine, UMHAT St. Marina, Faculty of Medicine, Medical University, Varna, Bulgaria


Objective: The aim of the present study was to assess the prevalence, risk rating and the severity of hazardous pDDIs (potential drug-drug interactions) in the prescribed pharmacotherapy in the hospital discharged heart failure (HF) patients, primarily with co-administered drugs with narrow therapeutic index (statins, anticoagulants, antithrombotic drugs).

Methods: The prescriptions of chronic heart failure patients for one year (January-December 2014) were analyzed for pDDIs through Lexi-interact® software. DDIs belonging to the categories D (Consider therapy modification) and X (Avoid combination) and/or severity of drug interaction-major, were selected for the study.

Results: After reviewing the medical records of 985 patients, 239 patients were selected based on the criteria mentioned above. The average number of prescription drugs at hospital discharge was 7.27 medications (±1.84 SD) per patient. The total number of pDDIs was 1483 or approximately 6.2 (±3.89 SD) pDDIs per patient. With respect to the risk rating, in categories D and X were detected 76 (5.12 %) and 2 (0.13 %) pDDI, respectively. The major pDDIs were 108 (7.28 %).

Conclusion: HF patients are at high risk of pDDIs. Screening of prescriptions for pDDIs and monitoring of pharmacotherapy in terms of response and associated adverse drug events will contribute to patient safety.

Keywords: Heart failure (HF), Drug-drug interactions (DDI), Anticoagulants, Statins, Antithrombotic drugs


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How to Cite
Georgiev, K., N. Hvarchanova, M. Georgieva, and B. Kanazirev. “POTENTIAL DRUG-DRUG INTERACTIONS IN HEART FAILURE PATIENTS”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 11, no. 9, Sept. 2019, pp. 37-41, doi:10.22159/ijpps.2019v11i9.33585.
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