A PRELIMINARY INVESTIGATION OF HTR1A GENE EXPRESSION LEVELS IN AUTISM SPECTRUM DISORDERS

  • SHAYMAA M. YAHYA Department of Hormones, Medical Research Division, National Research Centre, Giza, Egypt
  • OLA GEBRIL Department of Research on Children with Special Needs, Medical Research Division, National Research Centre, Giza, Egypt
  • EHAB R. ABDEL RAOUF Department of Research on Children with Special Needs, Medical Research Division, National Research Centre, Giza, Egypt
  • MOHAMED E. ELHADIDY Department of Research on Children with Special Needs, Medical Research Division, National Research Centre, Giza, Egypt

Abstract

Objective: This study was conducted to explore the expression levels of HTR1A gene in a sample of Egyptian autistic children.


Methods: Thirty autistic patients (18 boys, 12 girls) and 20 controls were enrolled in the study. From each child, we isolated RNA samples from whole blood. Quantitative Real-Time PCR (qRT-PCR) was used to measure the gene expressions of HTR1A and normalized to the house keeping gene, beta-actin.


Results: The HTR1A gene expression of healthy controls and ASD subjects were varied significantly (p =0.0062). As compared to control healthy subjects, the HTR1A expressions were greatly reduced in samples of ASD.


Conclusion: HTR1A gene expression level is a candidate gene for further studies to explore its potential roles in ASD related pathways.

Keywords: Autism spectrum disorders, Gene expressions, HTR1A gene expression

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YAHYA, S. M., O. GEBRIL, E. R. ABDEL RAOUF, and M. E. ELHADIDY. “A PRELIMINARY INVESTIGATION OF HTR1A GENE EXPRESSION LEVELS IN AUTISM SPECTRUM DISORDERS”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 11, no. 8, June 2019, pp. 1-3, doi:10.22159/ijpps.2019v11i8.34141.
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