INSIGHTS INTO FORMULATION TECHNOLOGIES AND NOVEL STRATEGIES FOR THE DESIGN OF ORALLY DISINTEGRATING DOSAGE FORMS: A COMPREHENSIVE INDUSTRIAL REVIEW

  • AHMED M. AGIBA Formulation Department, Research and Development Directorate, SIGMA Pharmaceutical Industries, Egypt
  • AHMED B. ELDIN Methodology Department, Research and Development Directorate, SIGMA Pharmaceutical Industries, Egypt

Abstract

Among the various routes of administration, the oral route remains the most convenient and commonly employed route for drug delivery. The oral conventional drug delivery systems have some drawbacks, such as possibility of gastrointestinal destruction of labile molecules, low absorption of macromolecules, slow onset of action, and unavoidable fluctuation in the concentration of drugs which can either lead to under- or over medication with concomitant adverse effects, especially for drugs with small therapeutic index. Therefore, it became essential to design novel oral drug delivery systems to achieve quick dissolution, absorption, rapid onset of action and reduction of drug dose. Among those novel drug delivery systems are oral disintegrating tablets (ODTs). The purpose of this review article is to report the recent advances in ODT systems with emphasis on their preparations, characterizations and applications.

Keywords: Oral disintegrating tablets, Patented technologies, Characterization methods, Applications, Future prospects

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Author Biography

AHMED M. AGIBA, Formulation Department, Research and Development Directorate, SIGMA Pharmaceutical Industries, Egypt

Senior Product Development Specialist and Pharmaceutical Researcher, Research and Development Department, SIGMA Pharmaceutical Industries

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AGIBA, A. M., and A. B. ELDIN. “INSIGHTS INTO FORMULATION TECHNOLOGIES AND NOVEL STRATEGIES FOR THE DESIGN OF ORALLY DISINTEGRATING DOSAGE FORMS: A COMPREHENSIVE INDUSTRIAL REVIEW”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 11, no. 9, Aug. 2019, pp. 8-20, doi:10.22159/ijpps.2019v119.34828.
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Review Article(s)