The SYNTHESIS, SCREENING OF NOVEL 1-SUBSTITUTED-3-(4-OXO-2-PHENYLQUINAZOLIN-3(4H)-yl) UREA AND THIOUREA ANALOGUES AS POTENT ANTIBACTERIALS

  • Deepali Amol Bansode Assistant Professor, Assistant Professor, Department of Pharmaceutical Chemistry, Bharati Vidyapeeth University, Poona College of Pharmacy, Pune, Maharashtra, India 411038. Mob. no: 09970002387, Fax: +91-020-25439383, E-mail:deepali_mhaske@rediffmail.com
  • Sandhya R Dhokale SD Research Associate
  • Snehal Thakar ST JRF
  • Kakasaheb Mahadik KM Principal, Poona College of Pharmacy.

Abstract

ABSTRACT


Objective


The proposed study is an attempt to determine antibacterial activity of synthesized novel 1-substituted-3-(4-oxo-2-phenylquinazolin-3(4H)-yl) urea and thiourea analogues as potent antibacterials against against S. aureus and E. coli bacteria.


Methods


Reagents used in the present study were of synthetic grade and solvents were used after distillation. Novel quinazolinone analogues were synthesized by considering substitution pattern, characterization of the synthesized analogues was performed using various techniques like Thin layer chromatography, Melting point, Infrared spectroscopy, Proton NMR spectrometry and Mass spectrometry.


 


Results


Six derivatives of quinazolinone analogues were synthesized. The structures of 1-substituted-3-(4-oxo-2-phenylquinazolin-3(4H)-yl) urea and thiourea derivatives were confirmed by physical and spectral analysis. The compounds were assayed for antibacterial activity against S. aureus and E. coli using ciprofloxacin as standard. The synthesized analogues have shown good yield and comparable antibacterial activity.


 


Conclusion


The present study delivers a convenient and efficient protocol for the quinazolinone analogues synthesis.


 

Keywords: KeywordsAntibacterial, Quinazolinone analogues, S. aureus, E. coli. Ciprofloxacin

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Author Biography

Deepali Amol Bansode, Assistant Professor, Assistant Professor, Department of Pharmaceutical Chemistry, Bharati Vidyapeeth University, Poona College of Pharmacy, Pune, Maharashtra, India 411038. Mob. no: 09970002387, Fax: +91-020-25439383, E-mail:deepali_mhaske@rediffmail.com
BVDU PCP is a renowned institute which had ranked 4th in NIRF amongst the Pharmacy institiutions in India. Reserach in our institute is the basis of our ranking.

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How to Cite
Bansode, D. A., S. R. D. SD, S. T. ST, and K. M. KM. “The SYNTHESIS, SCREENING OF NOVEL 1-SUBSTITUTED-3-(4-OXO-2-PHENYLQUINAZOLIN-3(4H)-Yl) UREA AND THIOUREA ANALOGUES AS POTENT ANTIBACTERIALS”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 11, no. 11, Oct. 2019, https://innovareacademics.in/journals/index.php/ijpps/article/view/35461.
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