CYTOTOXICITY STUDIES OF TETRAPRELYLTOLUQUINONE, A PRENILATED HYDROQUINONE FROM GARCINA COWA ROXB ON H-460, MCF-7 AND DU-145
Keywords:Garcinia cowa, TPTQ, H-460, MCF-7, DU-145, Cell viability, Cytotoxicity
Objective: The aim of the present study was to examine the cytotoxicity of a new ring-reduced tetra prenyltoluquinone (TPTQ), [2E,6E,10E]-(+)-4b-hydroxy-3-methyl-5b-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl-2-cyclohexen-1-one against H-460, MCF-7 and DU-145 cell lines.
Methods: Different concentrations of TPTQ were subjected to cytotoxicity study by using MTT method and calculate the percentage of cell viability.
Results: The results of this study showed that this compound has IC50 value 16.3 Â± 3.0 ÂµM in H-460 cancer cell lines without any activities towards another two type of cell lines.
Conclusion: TPTQ had selective activity against H-460 cancer cell lines.
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