EFFECT OF BLUMEA LACERA ON TISSUE GSH, LIPID PEROXIDATION AND HEPATIC CELLS IN ETHANOL INDUCED HEPATOTOXICITY IN RATS

  • DEVENDRA S. SHIRODE Department of Pharmacology, Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune 411044
  • ASHISH V. KULKARNI Department of Pharmacology, Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune 411044
  • BRIJENDRA B. JAIN Indrayani Institute of Pharmaceutical Education and Research, Talegaon Dabhade, Pune 410507

Abstract

Objective: To evaluate hepatoprotective effects of ethanol extract of aerial part of Blumea lacera (BLEE) against ethanol-induced hepatotoxicity in rats.


Methods: The in vivo antioxidant activity of BLEE was assessed by determining the tissue glutathione (GSH) and lipid peroxidation (LPO) levels. The BLEE at the doses of 200 and 400 mg/kg and silymarin 100 mg/kg administered to the ethanol challenged rats. The effects of BLEE and silymarin on Physical and Biochemical Parameters were measured. Similarly, histopathological changes of the liver were studied.


Results: The BLEE showed in vivo antioxidant activity. A significant (P<0.001) decrease in SGOT, SGPT, ALP, total and direct bilirubin was observed in BLEE treated group at doses i.e. 200 mg/kg and 400 mg/kg as compared to intoxicated group. Liver damage in animal pretreated with BLEE was minimal with distinct preservation of structures and the architectural frame of the hepatic cells.


Conclusion: These findings demonstrated the hepatoprotective effects of BLEE against ethanol-induced liver damage.

Keywords: Blumea lacera, Hepatoprotective, In vivo antioxidant, Ethanol

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SHIRODE, D. S., A. V. KULKARNI, and B. B. JAIN. “EFFECT OF BLUMEA LACERA ON TISSUE GSH, LIPID PEROXIDATION AND HEPATIC CELLS IN ETHANOL INDUCED HEPATOTOXICITY IN RATS”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 11, no. 12, Dec. 2019, pp. 46-50, doi:10.22159/ijpps.2019v11i12.36453.
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