SCREENING AND ANTIBIOGRAM PATTERN OF BACTERIAL OPHTHALMIC INFECTIONS
Keywords:
Ophthalmic infection, Antibiotics, Multidrug resistance, Plasmid DNAAbstract
Objective: Microbial infections are causing life threatening diseases of which ocular infection is of primary importance, as it can even led to blindness. In order to understand the etiological agents causing bacterial ocular infection, this present study was aimed in screening and understanding the anti biogram pattern of bacterial ophthalmic infections.
Methods: Pus and corneal scrapings were collected from 50 ocular infected patients and were screened for bacterial pathogens for a three months period.
Results: Out of them 88% (44/50) were culture positive. The ocular pathogenic isolates include Staphylococcus spp (70.45%), Streptococcus spp (22.72%), Bacillus spp, Enterobacter spp and Serratia spp (2.27%). Sex and age wise perspective of ocular infections indicated that females and adults between 21-40 years were highly infected. Antibiotic susceptibility pattern of the isolates revealed that the modern antibiotics namely Moxifloxacin, Ofloxacin, Levofloxacin, Ceftazidime, Cefepime, Vancomycin, Rifampicin exhibited high sensitivity than the conventional antibiotics like methicillin, bacitracin, and oxytetracycline. Isolates exhibited multidrug resistance viz., Staphylococcus aureus (52.63%), Staphylococcus epidermidis (75%), Streptococcus spp (80%), Enterobacter spp (100%). Isolation of drug resistant plasmid DNA showed that multidrug resistant isolates harbor high molecular weight plasmid.
Conclusion: All the isolates exhibited the antibiotic resistance to conventional antibiotics, and were sensitive to the current antibiotics.
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References
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