EVALUATION OF GLOMERULAR FILTRATION RATE ESTIMATING EQUATIONS IN CKD PATIENTS WITH DIABETES AND HYPERTENSION

GANESH SRITHERAN  PANEERSELVAM; YAMAN WALID  KASSAB

doi:10.22159/ijpps.2020v12i4.37120

GANESH SRITHERAN PANEERSELVAM School of Pharmacy, Taylors University, 47500 Subang Jaya, Selangor
YAMAN WALID KASSAB Faculty of Pharmacy, Cyberjaya University College of Medical Sciences, 63000 Cyberjaya, Selangor, Malaysia

DOI https://doi.org/10.22159/ijpps.2020v12i4.37120

Abstract

Objective: To compare the performance of Cockcroft-Gault and Modification of Diet in Renal Disease (MDRD) equations in estimating kidney function in CKD patients with diabetes and hypertension.

Methods: This study retrospectively reviewed medical records in Hospital Kajang. The GFR was calculated using Cockcroft-Gault and MDRD equations. Kappa Measure of Agreement was used to check the consistency of CKD staging. Wilcoxon signed-ranked tests and Bland-Altman plots were used to determine the difference of both equations. Spearman correlation was used to determine the correlation between blood pressure and blood sugar levels with eGFR.

Results: Data pertaining to a total of 81 patients were extracted. Results showed 22% of the patients were staged differently (Kappa value = 0.644 [P<0.001]) and the majority of them moved down one CKD stage when MDRD equation was used instead of Cockcroft-Gault equation. Wilcoxon signed rank test demonstrated there was a significant difference (P<0.001) in eGFR using CandG and MDRD in patients with diabetes and hypertension. Furthermore, the mean difference observed was 3.78±5.56 [P<0.001]), where the Cockcroft-Gault equation measured 3.78 units higher than MDRD equation. However, the relationship between blood sugar and blood pressure with eGFR were not significant.

Conclusion: There was a significant difference between Cockcroft-Gault and MDRD equations in estimating kidney function CKD patients with diabetes and hypertension.

Keywords: Chronic kidney disease, Estimated glomerular filtration rate, Cockcroft-Gault, Modification of diet in renal disease

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