FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF LAMOTRIGINEUSING DISCRETE SUPER DISINTEGRANTS AND COPROCESSED EXCIPIENTS

  • RAJASEKHAR POONURU Principal and Head, Department of Pharmaceutics, St. Peter’s Institute of Pharmaceutical Sciences
  • ROHINI CHERUKU Students, Department of Pharmaceutics, St. Peter’s Institute of Pharmaceutical Sciences
  • PAVAN JULURI Students, Department of Pharmaceutics, St. Peter’s Institute of Pharmaceutical Sciences
  • KHADEERA JABEEN Students, Department of Pharmaceutics, St. Peter’s Institute of Pharmaceutical Sciences
  • SWETHA SREERAMULA Students, Department of Pharmaceutics, St. Peter’s Institute of Pharmaceutical Sciences
  • SNEHA BANDARI Students, Department of Pharmaceutics, St. Peter’s Institute of Pharmaceutical Sciences
  • AKHILA MADUPU Students, Department of Pharmaceutics, St. Peter’s Institute of Pharmaceutical Sciences

Abstract

Objective: The present study was designed to formulate and evaluate the orodispersible tablets of lamotrigine after enhancing its solubility.


Methods: Lamotrigine was made into an inclusion complex with eudragit E 100 my kneading and mass extrusion method and later this mixture is compressed into orodispersible tablet using various super disintegrants and co-processed excipients to reduce the disintegration time for providing prompt action through rapid drug release.


Results: Lamotrigine ODTs containing F-melt (F1-3%, F2-5%) dispersed in lesser time of (9±0.11) and (21±0.58) compared to formulations with polyplasdone XL-10 and primellose as super disintegrants respectively with F1 showing short wetting time. The water absorption was also was found to be more for formulation with 3% F-Melt.


Conclusion: Lamotrigine orodispersible tablets were prepared by direct compression technique by using 3% and 5% of three super disintegrants (f-melt, primellose and polyplasdone XL-10). Disintegration time of F1 (3% f-melt) formulation was found to be least (7 sec).

Keywords: Tablets of lamotrigine using, Coprocessed excipients

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POONURU, R., R. CHERUKU, P. JULURI, K. JABEEN, S. SREERAMULA, S. BANDARI, and A. MADUPU. “FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF LAMOTRIGINEUSING DISCRETE SUPER DISINTEGRANTS AND COPROCESSED EXCIPIENTS”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 12, no. 6, Apr. 2020, pp. 28-35, doi:10.22159/ijpps.2020v12i6.37567.
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