• jhvirupaksha jalimara national college of pharmacy,shivamogga-577201



Objective: The present study was aimed to investigate the antidiabetic activity of ethanolic and aqueous extract of Zanthoxylum ovalifolium on alloxan induced diabetic rat model in rats.

Materials and Methods: The Zanthoxylum ovalifolium leaves were evaluated for antidiabetic activity by using alloxan induced diabetic model in diabetic rats. Diabetes was induced by single intraperitoneal injection of alloxan (100 mg/kg) and rats were treated orally with test extracts, standard drug (glibenclamide 5mg/kg) and vehicle for 21 days. The hypoglycemic effects and lipid profile of diabetic rats were assessed. Finally, histopathological studies were carried out for pancreas.

Results: The acute toxicity studies revealed at the dose of 2000 mg/kg (b.w) of Zanthoxylum ovalifolium for ethanol and aqueous extract was found to be safe. Daily oral treatment with the test extracts and the standard drug for 21 days significantly reduced blood glucose, total cholesterol triglyceride, high-density lipoprotein, low density lipoprotein and very low-density lipoproteins levels in time and dose dependent fashion when compare to control groups. Further histopathological studies also confirmed regeneration of β-cells in the extract treated groups.

Conclusion: It can be concluded that ethanol and aqueous extract of Zanthoxylum ovalifolium at high dose (400 mg/kg) exhibited significant antihyperglycemic activity than extract at low dose (200 mg/kg) in alloxan induced diabetic rats. These extracts also showed improvement in parameters like lipid profile as well as regeneration β-cells in pancreas and so might be of value in diabetes treatment.

Keywords: Zanthoxylum ovalifolium, antidiabetic activity, lipid profile, alloxan and glibenclamide.

Keywords: Keywords: Zanthoxylum ovalifolium, antidiabetic activity, lipid profile, alloxan and glibenclamide.


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jalimara, jhvirupaksha. “Antidiabetic Activity EVALUATION OF ANTIDIABETIC ACTIVITY OF ZANTHOXYLUM OVALIFOLIUM LEAF EXTRACTS: EVALUATION OF ANTIDIABETIC ACTIVITY OF ZANTHOXYLUM OVALIFOLIUM LEAF EXTRACTS”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 13, no. 2, Jan. 2021,
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