BANANA PEEL FLAKES ALLEVIATE BLOOD GLUCOSE AND STRESS IN A DOSE-DEPENDENT MANNER

  • ANDREANYTA MELIALA Department of Physiology, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Jalan Farmako Sekip Utara, Sleman, Yogyakarta 55281, Indonesia
  • YUSTINA ANDWI ARI SUMIWI Department of Histology, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Jalan Farmako Sekip Utara, Sleman, Yogyakarta 5528, Indonesia
  • PARAMITA NARWIDINA Clinical Nutrition Research Group, Yogyakarta 55133, Indonesia
  • SRI LESTARI SULISTYO RINI Department of Physiology, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Jalan Farmako Sekip Utara, Sleman, Yogyakarta 55281, Indonesia
  • WIDIASTUTI SETYANINGSIH Department of Food and Agricultural Product Technology, Faculty of Agricultural Technology, Gadjah Mada University, Jalan Flora, Bulaksumur, Sleman, Yogyakarta 55281, Indonesia

Abstract

Objective: This study aimed to evaluate the antidiabetic and antidepressant effects of banana peel flakes in streptozotocin-induced diabetic rats.


Methods: Twenty-five male Wistar rats were classified into five groups with different treatments. Groups I to IV were diabetic rats model groups that consumed only standard diet, standard diet containing 5%, 10%, and 20% of banana peel flakes, respectively. While group V was a healthy control group fed a standard diet. Immunohistochemistry staining was measured to examine serotonin expression in the colon and pancreas.


Results: The diabetic rats treated with 20% banana peel flakes had a lower blood glucose concentration (p<0.05) compared with diabetic control and showed a shorter duration of immobility time (p<0.05) than the healthy control. Additionally, compared with diabetic control, the diabetic rats treated with 5% banana peel flakes showed higher serotonin expression (p<0.05) in the colon. In contrast, serotonin expression in the pancreas did not show any significant difference (p>0.05).


Conclusion: The present study disclosed that the banana peel flakes provided an antidepressant effect in the diabetic rats model, which might occur through the mechanism of controlling blood glucose concentration.

Keywords: Banana peel, Antidiabetic, Antidepressive, Dietary fiber, Serotonin

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MELIALA, A., Y. A. A. SUMIWI, P. NARWIDINA, S. L. S. RINI, and W. SETYANINGSIH. “BANANA PEEL FLAKES ALLEVIATE BLOOD GLUCOSE AND STRESS IN A DOSE-DEPENDENT MANNER”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 12, no. 8, June 2020, pp. 75-81, doi:10.22159/ijpps.2020v12i8.37659.
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