Changes in haemostatic parameters of wistar rats following repeated administration of aqueous extract of brown onion (AllumcepaL.)
Different onion varieties have been linked to both haemostatic and anti-haemostatic effect. The study investigated changes in haemostatic parameters such as bleeding time, blood clotting time and differential platelet counts of wistar rats following repeated administration of aqueous extract of allum cepa L. Rats were divided into four groups of four rats (n=4) animals. Group I served as normal control, Group II, group III and group IV were administered with received 25mg/kg b w, 50mg/kg b w and 100mg/kg b w of the extract intra-peritoneally for a period of two weeks respectively. After 14 days experimental period, blood samples were collected for the determination of bleeding time, clotting time and differential platelets count. The findings of this study revealed a significantly increased clotting time at a dose of 25mg/kg but showed no significant change in bleeding time and differential platelet count of all the groups. In conclusion, aqueous extract of brown onion showed anti haemostatic effect in albino rats at low dose.
Key words; Bleeding time, Clotting time, Allumcepa, Haemostasis, Rats.
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