CHANGES IN HAEMOSTATIC PARAMETERS OF WISTAR RATS FOLLOWING REPEATED ADMINISTRATION OF AQUEOUS EXTRACT OF BROWN ONION (ALLUMCEPAL.)
DOI:
https://doi.org/10.22159/ijpps.2021v13i5.37673Keywords:
Bleeding time, Clotting time, Allumcepa, Haemostasis, RatsAbstract
Objective: The study investigated changes in haemostatic parameters such as; bleeding time, blood clotting time and differential platelet counts of wistar rats following repeated administration of aqueous extract of allum cepa L.
Methods: Rats were divided into four groups of four animals each (n=4). Group I served as normal control, Group II, group IIIand group IV were administered 25 mg/kg bw, 50 mg/kg bw and 100 mg/kg bw of the extract intra-peritoneally for two weeks, respectively. After 14 d experimental period, blood samples were collected for the determination of bleeding time, clotting time and differential platelet count.
Results: The findings of this study revealed a significantly increased (p<0.05) clotting time at a dose of 25 mg/kg but showed no significant change in bleeding time and differential platelet count of all the groups.
Conclusion: Aqueous extract of brown onion showed anti haemostatic effect in albino rats by increasing clotting time at a lower dose.
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