• PRASANTA KUMAR MOHAPATRA Moradabad Educational Trust Group of Institutions Faculty of Pharmacy, Moradabad 244001, Uttar Pradesh, India
  • C. H. SATYAVANI Lydia College of Pharmacy, Ravulapalem 533238, Andhra Pradesh, India
  • SATYAJIT SAHOO C. U. Shah College of Pharmacy and Research, Surendranagar 363001, Gujrat, India


Objective: The primary aim of the present examination was to create carvedilol phosphate floating tablets using factorial designs and for retention in the upper portion of the gastrointestinal (GI) tract to sustain the dissolution where the solubility of carvedilol phosphate is more in an acidic medium.

Methods: The floating tablets of carvedilol phosphate were ready to employ different concentrations and a combination of these polymers of Na-alginate, Carbopol 934P, and sodium carboxymethyl cellulose (NaCMC) with lubricants magnesium stearate by direct compression technique. In the present experiment, involved sodium bicarbonate and citric acid as a gas-producing agent. Fifteen formulations structured and judged for pre-compression components like the angle of repose, bulk and tapped density, Hausner’s ratio, compressibility index, and post-compression factors are weight uniformity, hardness, drug content, friability, in vitro buoyancy, dissolution studies, and Fourier transforms infrared spectroscopy (FTIR).

Results: The drug released 90.02% in 12 h by combining NaCMC (7.5 mg) and Na-alginate (7.5 mg) in the formulation F14 towards the achievement of sustained release. Batch F14 selected as optimized, as provided desired zero-order release profile as well as floating lag time 20 s and total floating time>12 h, and the mechanism of drug release observed (n = 1.098, super case-II transport).

Conclusion: From the results fulfilled that all the preparation found to be within the pharmacopeia limits and was the best dosage form to treat moderate heart failure and hypertension. The in vitro dissolution profiles of all formulations placed into various kinetic models, the statistical parameters like slope, regression coefficient and intercept determined. The gastro-retentive dosage form to maintain the sustain drug delivery, which would improve the maximum therapeutic efficacy and patient compliance.

Keywords: Carvedilol phosphate, Gastroretentive dosage form, Factorial design, Direct compression method


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Author Biographies

PRASANTA KUMAR MOHAPATRA, Moradabad Educational Trust Group of Institutions Faculty of Pharmacy, Moradabad 244001, Uttar Pradesh, India

Associate Professor,

Pharmaceutics Department 

C. H. SATYAVANI, Lydia College of Pharmacy, Ravulapalem 533238, Andhra Pradesh, India

Lydia College of Pharmacy, Ravulapalem- 533 238, Andhra Pradesh, India

SATYAJIT SAHOO, C. U. Shah College of Pharmacy and Research, Surendranagar 363001, Gujrat, India

C. U. Shah College of Pharmacy and Research, Surendranagar- 363 001, Gujrat, India.


1. Bala R, Pawar P, Khanna S, Arora S. Orally dissolving strips: a new approach to oral drug delivery system. Int J Pharm Investigation 2013;3:67-76.
2. Moes AJ. Gastroretentive dosage forms. Crit Rev Ther Drug Carrier Syst 1993;10:143?95.
3. Borase CB. Floating systems for oral controlled release drug delivery. Int J Appl Pharm 2012;4:1-13.
4. Srilekha V, Dhanalakshmi Dr M. Development and evaluation of floating tablets for gastric retention using silymarin as a model drug. World J Pharm Med Res 2018;4:242-53.
5. Chilukala S. Gastro retentive drug delivery of cyclobenzaprine hydrochloride. J Gastroenterol Pancreatol Hepatobilary Disorders 2018;2:1-3.
6. Pattan SR, Wani NP, Shelar MU, Nirmal SA, Chaudhari PD, Gude RS, et al. Scope and significance of floating drug delivery system. Indian Drugs 2012;49:5-12.
7. Iannucelli V, Coppi G, Bernabei MT, Camerorni R. Aircompertment multiple-unit system for prolonged gastric residence. Part-I. Formulation study. Int J Pharm 1998;174:47-54.
8. Garg R, Gupta GD. Progress in controlled gastroretentive delivery systems. Trop J Pharm Res 2008;7:1055-66.
9. Rouge N, Buri P, Doelker E. Drug absorption sites in the gastrointestinal tract and dosage forms for site-specific delivery. Int J Pharm 1996;136:117-39.
10. Joshi P, Patel M, Patel N. Design and development of carvedilol phosphate floating microsphere: formulation and in vitro evaluation of carvedilol phosphate floating microsphere. 1st ed. LAP LAMBERT Academic Publishing; 2013.
11. Avachat AM, Patel KB, Rokade MS, Dash RR. Formulation and characterization of an expandable gastroretentive system of carvedilol phosphate by 32 factorial design. PDA J Pharm Sci Technol 2011;65:12-9.
12. Chakraborty S, Shukla D, Jain A. Assessment of solubilization characteristics of different surfactants for carvedilol phosphate as a function of pH. J Colloid Interface Sci 2009;335:242-9.
13. Agrawal SS, Aggarwal A. Randomised, cross-over, comparative bioavailability trial of the matrix type transdermal drug delivery system of carvedilol and hydrochlorothiazide combination in healthy human volunteers: a pilot study. Contemporary Clin Trials 2010;31:272-8.
14. Sravya K, Kavitha K, Kumar MR, Singh SDJ. Gastroretentive drug delivery systems: a review. Res J Pharm Bio Chem Sci 2012;3:965-80.
15. Gunda RK. Formulation development and evaluation of rosiglitazone maleate sustained-release tablets using 32 factorial design. Int J Pharm Tech Res 2015;8:713-24.
16. Gunda RK, Kumar JNS, Satyanarayana V, Ramanjaneyulu KV, Prasad BS. Formulation development and evaluation of carvedilol phosphate gastro retentive floating tablets. Int Res J Pharm 2016;7:44-51.
17. Panda S, kumari CHS, Puniya G. Formulation and evaluation of compression coating floating tablets of carvedilol phosphate once-daily dose. Int J Pharm Pharm Sci 2018;10:82-9.
18. Thakkar HKR, Senthil A, Gajendrasinh AC, Patel JN, Narayanswamy VB. Formulation and evaluation of gastro retentive floating tablets of gliclazide. Int J Res Ayurveda Pharm 2011;2:1368-73.
19. Patel SG, Siddaiah M. Formulation and evaluation of effervescent tablets: a review. J Drug Delivery Thera 2018;8:296-303.
20. Singh N, Bose A, Mishra RK, Jain V, Dhakar S, Bharati D, et al. Development and evaluation of gastroretentive floating drug delivery system for tizanidine hydrochloride and its in vivo gamma-scintigraphic studies using tc-99m tracer. Asian J Pharm Clin Res 2012;5:56-61.
21. Thahera PD, Latha AK, Shailaja T, Nyamathulla S, Uhumwangho MU. Formulation and evaluation of Norfloxacin gastro retentive drug delivery systems using natural polymers. Int Curr Pharm J 2012;1:155-64.
22. Chinnala KM, Panigrahy RN, Bantu R, Reddy GK. Formulation and in vitro evaluation of sustained-release floating matrix tablet of rosiglitazone maleate. Int J Drug Dev Res 2015;7:1-9.
23. Velmurugan S, Chaitanya K. Formulation and evaluation of levodopa effervescent floating tablets. Int J Pharm Pharm Sci 2015;7:189-93.
24. Pawar HA, Dhavale R. Development and evaluation of gastroretentive floating tablets of an antidepressant drug by thermoplastic granulation technique. Beni-Suef University J Basic Appl Sci 2014;3:122-32.
25. Kalam MA, Humayun M, Parvez N, Yadav S, Garg A, Amin S, et al. Release kinetics of modified pharmaceutical dosage forms: a review. Continental J Pharm Sci 2007;1:30-5.
26. Hadjiioannou TP, Christian GD, Koupparis MA. Quantitative calculation in pharmaceutical practice and research. 3rd ed. New York: VCH Publishers; 1993.
27. Korsmeyer RW, Gunny R, Docler E, Buri P, Peppas NA. Mechanisms of solute release from porous hydrophilic polymers. Int J Pharm 1983;15:25-35.
28. Higuchi T. Mechanism of sustained action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J Pharm Sci 1963;51:1145-9.
29. Hixon AW, Crowell JH. Dependence of reaction velocity upon surface and agitation. Ind Eng Chem 1931;23:923-31.
30. Peppas NA. Analysis of fickian and non-fickian drug release from polymers. Pharm Acta Helvetiae 1985;60:110-1.
31. Joshi P, Patel MR, Patel KR, Patel NM. Design and development of carvedilol phosphate floating microsphere. Int J Pharm India 2013;1:557-71.
32. Rowe RC, Sheskey PJ, Quinn ME. Handbook of pharmaceutical excipients. 6th ed. USA: Pharmaceutical press and the American Pharmacists Association; 2009.
33. Peppas NA, Sahlin JJ. A simple equation for the description of solute release. Coupling of diffusion and relaxation. Int J Pharm 1989;57:169-72.
34. Peppas NA, Ritger PL. A simple equation for description of solute release. Fickian and anomalous release from swellable devices. J Controlled Release 1987;5:37-42.
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How to Cite
MOHAPATRA, P. K., C. H. SATYAVANI, and S. SAHOO. “The DESIGN AND DEVELOPMENT OF CARVEDILOL GASTRORETENTIVE FLOATING DRUG DELIVERY SYSTEMS USING HYDROPHILIC POLYMERS AND IN VITRO CHARACTERIZATION”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 12, no. 7, July 2020, pp. 66-73, doi:10.22159/ijpps.2020v12i7.38024.
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