The DESIGN AND DEVELOPMENT OF CARVEDILOL GASTRORETENTIVE FLOATING DRUG DELIVERY SYSTEMS USING HYDROPHILIC POLYMERS AND IN VITRO CHARACTERIZATION

  • PRASANTA KUMAR MOHAPATRA Moradabad Educational Trust Group of Institutions Faculty of Pharmacy, Moradabad 244001, Uttar Pradesh, India
  • C. H. SATYAVANI Lydia College of Pharmacy, Ravulapalem 533238, Andhra Pradesh, India
  • SATYAJIT SAHOO C. U. Shah College of Pharmacy and Research, Surendranagar 363001, Gujrat, India

Abstract

Objective: The primary aim of the present examination was to create carvedilol phosphate floating tablets using factorial designs and for retention in the upper portion of the gastrointestinal (GI) tract to sustain the dissolution where the solubility of carvedilol phosphate is more in an acidic medium.


Methods: The floating tablets of carvedilol phosphate were ready to employ different concentrations and a combination of these polymers of Na-alginate, Carbopol 934P, and sodium carboxymethyl cellulose (NaCMC) with lubricants magnesium stearate by direct compression technique. In the present experiment, involved sodium bicarbonate and citric acid as a gas-producing agent. Fifteen formulations structured and judged for pre-compression components like the angle of repose, bulk and tapped density, Hausner’s ratio, compressibility index, and post-compression factors are weight uniformity, hardness, drug content, friability, in vitro buoyancy, dissolution studies, and Fourier transforms infrared spectroscopy (FTIR).


Results: The drug released 90.02% in 12 h by combining NaCMC (7.5 mg) and Na-alginate (7.5 mg) in the formulation F14 towards the achievement of sustained release. Batch F14 selected as optimized, as provided desired zero-order release profile as well as floating lag time 20 s and total floating time>12 h, and the mechanism of drug release observed (n = 1.098, super case-II transport).


Conclusion: From the results fulfilled that all the preparation found to be within the pharmacopeia limits and was the best dosage form to treat moderate heart failure and hypertension. The in vitro dissolution profiles of all formulations placed into various kinetic models, the statistical parameters like slope, regression coefficient and intercept determined. The gastro-retentive dosage form to maintain the sustain drug delivery, which would improve the maximum therapeutic efficacy and patient compliance.

Keywords: Carvedilol phosphate, Gastroretentive dosage form, Factorial design, Direct compression method

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Author Biographies

PRASANTA KUMAR MOHAPATRA, Moradabad Educational Trust Group of Institutions Faculty of Pharmacy, Moradabad 244001, Uttar Pradesh, India

Associate Professor,

Pharmaceutics Department 

C. H. SATYAVANI, Lydia College of Pharmacy, Ravulapalem 533238, Andhra Pradesh, India

Lydia College of Pharmacy, Ravulapalem- 533 238, Andhra Pradesh, India

SATYAJIT SAHOO, C. U. Shah College of Pharmacy and Research, Surendranagar 363001, Gujrat, India

C. U. Shah College of Pharmacy and Research, Surendranagar- 363 001, Gujrat, India.

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MOHAPATRA, P. K., C. H. SATYAVANI, and S. SAHOO. “The DESIGN AND DEVELOPMENT OF CARVEDILOL GASTRORETENTIVE FLOATING DRUG DELIVERY SYSTEMS USING HYDROPHILIC POLYMERS AND IN VITRO CHARACTERIZATION”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 12, no. 7, May 2020, pp. 66-73, doi:10.22159/ijpps.2020v12i7.38024.
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