DENSIO-VISCOMETRIC STUDIES OF TIO2-MCM-41 IN ETHANOLIC NICOTINAMIDE SOLUTIONS AND ITS APPLICATION IN DRUG DELIVERY OF IBUPROFEN

  • Srabani Swagatika Sikhya o Anusandhan University,Bhubaneswar,Odisha,India
  • Agnimitra Dinda ‘O’AnusandhanUniversity
  • Suresh Kumar Dash Department of Chemistry
  • Upendra Nath Dash Department of Chemistry

Abstract

Objective: To study the density, viscosity of the solutions of TiO2-MCM-41 in the presence of nicotinamide as hydrotropic agent in ethanol solvent at different temperatures ranging from 298.15K to 313.15K at an interval of 5K, and its application as a drug delivery system.

Methods: 10 and 15 weight percentages of TiO2-MCM-41 were synthesized via co-condensation method using cetyl hexadecyltrimethyl ammonium bromide (CTAB) as structure directing agent, tetraethylorthosilicate(TEOS) as silica source and Degussa P-25 as titania source. The characterization of the prepared samples was done by powdered XRD, Fourier Transformed-Infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and DSC. Its drug delivery activity was also studied taking Ibuprofen as test drug.

Results: Characterization result indicated that TiO2-MCM-41 retained the mesoscopic morphology and porous structure. The results of density and viscosity measurements have been discussed in the light of molecular interactions. It was found that TiO2-MCM-41 have lower density and viscosity in comparison to parent MCM-41, whereas (15)TiO2-MCM-41 shows highest solute-solvent interaction and lowest solute-solute interaction in ethanol in presence of nicotinamide and exhibited highest drug release capacity.

Keywords: TiO2-MCM-41, Ethanol, Nicotinamide, Partial molar properties, Viscosity co-efficient, Drug delivery application.

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How to Cite
Swagatika, S., A. Dinda, S. K. Dash, and U. N. Dash. “DENSIO-VISCOMETRIC STUDIES OF TIO2-MCM-41 IN ETHANOLIC NICOTINAMIDE SOLUTIONS AND ITS APPLICATION IN DRUG DELIVERY OF IBUPROFEN”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 7, no. 2, Dec. 2014, pp. 571-7, https://innovareacademics.in/journals/index.php/ijpps/article/view/3806.
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