CYTOTOXIC ACTIVITY OF METHANOLIC EXTRACTS OF SOLANUM ERIANTHUM D. DON

  • Radhika Mahadev Kuvempu University
  • H. Ramakrishnaiah Government Science College
  • V. Krishna Kuvempu University
  • A. P. Deepalakshmi Government Science College
  • N. Naveen Kumar Government Science College

Abstract

Objective: The study was aimed to evaluate cytotoxic activity of the methanolic extracts of Solanum erianthum on HeLa, HepG-2 and MCF-7 cell lines.

Methods: The percentage viability of the cell lines were carried out using trypan blue dye exclusion method and the cytotoxicity of the extracts was evaluated by MTT assay.

Result: Solanum erianthum leaf and fruit extract showed significant cytotoxic activity on the tested cell lines with IC50 values ranging from 111.67 to 385 µg mL-1. Fruit extract showed potent cytotoxic activity on MCF-7 (IC50 111.67 µgmL-1), followed by leaf extract (IC50 150.50 µgmL-1)on HeLa cell line using MTT assay. Cell viability assay showed that fruit extract was very active on MCF-7 and leaf extract was effective against HeLa.

Conclusion: The experiment performed reveals that Solanum erianthum can be used in development of anticancer drug.

 

Keywords: Solanum erianthum, Cytotoxic activity, MTT assay, Trypan blue assay, HeLa, HepG-2, MCF-7

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Author Biography

Radhika Mahadev, Kuvempu University
Research scholar, Department of PG Studies and Research in Biotechnology,  Govt Science College,

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How to Cite
Mahadev, R., H. Ramakrishnaiah, V. Krishna, A. P. Deepalakshmi, and N. N. Kumar. “CYTOTOXIC ACTIVITY OF METHANOLIC EXTRACTS OF SOLANUM ERIANTHUM D. DON”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 7, no. 2, Dec. 2014, pp. 106-8, https://innovareacademics.in/journals/index.php/ijpps/article/view/3813.
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