ETORICOXIB-LOADED SOLID LIPID NANOPARTICLE DOSAGE FORM: FORMULATION, OPTIMIZATION, CHARACTERIZATION, STABILITY STUDYAND IN-VITRO IN-VIVO EVALUATION
Objective: The aim of present research work is to increase the bioavailability of poorly water soluble drug etoricoxib by developing solid lipid nanoparticle (SLN). Due to their unique size dependent properties, lipid nanoparticles offer the possibility to develop new therapeutics and enhance the bioavailability.
Methods: An aqueous-based etoricoxib loaded solid lipid nanoparticles were prepared by hot and high speed homogenization technique, using different ratio of stearic acid and tripalmitin as lipid and different amount of pluronic F-68 as emulsifier. Optimization was done by surface response methodology (SRM) technique. The formulations are charecterised by drug content, drug entrapment efficiency, particle size and zea potential determination, SEM etc and evaluated by pharmacokinetic, pharmacodynamic and stability study.
Results: Particle size distribution, entrapment efficiency and drug release were found 499.20 nm, 72% and 98.36% simultaneously, for selected optimized formulations. Zeta potential and span of optimized formulation found to be within the range of+34.2Â±0.9 and 0.29. in-vivo studies shows that pain reaction time (PRT) has increased from 6.2Â±0.42 to 8.45Â±0.19 second. Pharmacokinetic study shows an increasing remarkable result for Cmax which one is increased from 6274.290 Î¼g mlâˆ’1 h to 8558.134 Î¼g mlâˆ’1 h when compared with the standard formulation and for AUC it has been observed from 94202.963 mg. h. l-1 to 124310.201 mg. h. l-1
Conclusion: Development of SLN formulations could be a better approach to increase the bioavailability of poorly water soluble drug like etoricoxib.
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