EVALUATION OF EXCISIONAL AND INCISIONAL WOUND HEALING ACTIVITY OF ELECTROHOMEOPATHIC DRUG (SPAGYRIC ESSENCE) GREEN ELECTRICITY IN RATS

  • PRASANT KUMAR SABAT School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan (Deemed to be) University, Kalinga Nagar, Bhubaneswar, 751003, Odisha, India
  • SWETA PRIYADARSINI PRADHAN School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan (Deemed to be) University, Kalinga Nagar, Bhubaneswar, 751003, Odisha, India
  • RANDEEP PATRO School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan (Deemed to be) University, Kalinga Nagar, Bhubaneswar, 751003, Odisha, India

Abstract

Objective: The current research is an attempt to evaluate the wound healing activity of Electrohomeopathic drug Green electricity (GE) in Wistar rats. No data have been reported till date on the wound healing effect of GE. Hence the present research focuses on the scientific investigation of the wound healing activity of GE in rats.


Methods: Excision and incision wounds were inflicted upon albino rats. In the excision wound model, the wound contraction, Scar residue, area and time of complete epithelization were measured subsequently on day 0, 3,6,9,12,15, 18 and 21 after inflicting the wound. Wound contraction was calculated as a percentage change in the initial wound size. In the incision wound model, the tensile strength was measured on the 10th post wounding day.


Results: It was noted that the effect produced by the GE Showed significant wound healing (p<0.01) in all wound models when compared to the control group. In the case of the excision model, GE statistically increases the wound contraction rate and in the case of the incision model GE showed high tensile strength as compared to the control group. In both cases the epithelization period was significantly decreased as compared to control. Almost 100% wound protection was achieved by GE in 21 d as compared to control.


Conclusion: GE (ointment) showed significant wound healing activity (p<0.01) in both the excised wound model and incision wound model in rats.

Keywords: Electrohomeopathy, Green electricity, Excision, Incision

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References

1. Sureshbabu P, Siddalingamurty E, Sashidhara NL, Sooryanarayanarao B, Bhavya DC. A review on electrohomeopathic medicinal practice: origin, principles, medicinal plants used and its current status in India. Euro J Med Plants 2020;8:31-47.
2. Sudha Bhargavi CH, Swami V, Bilal S, Ushasri S, Kumar R. Wound healing activity of alcoholic extract of Solanum erianthum D. Don in excision and incision method. Int J Res Ayur Pharm 2013;4:130-5.
3. Biswas TK, Mukherjee B. Plant medicines of Indian origin for wound healing activity, a review. Int J Lower Extrem Wounds 2003;2:25.
4. British Pharmacopia; 1980. p. 1096.
5. Mohanty A, Pal A, Sahu PK. Wound healing activity of Baringtonia acutangula fruit extract. Asian J Pharm Clin Res 2016;9:236-8.
6. Smitarani RK, Remya K, Bency BT, Shebina PR, Azeem AK, Sajeev VK. Investigation on the wound healing activity of aqueous extract of Emilia sonchifolia (L.) Dc. Int J Herb Med 2017;5:34-9.
7. Morton JJP, Malone MH. Evaluation of vulnerary activity by an open wound procedure in rats. Arch Int Phamacodyn Ther 1972;196:117-26.
8. Ghosh S, Samanta A, Mandal NB, Banerjee S. Evaluation of the wound healing activity of methanol extract of Pedilanthus tithymaloids (L.) poit leaf and its isolated active constituents in topical formulation. J Ethnopharmacol 2012;142:714-22.
9. Chitra P, Sajithal GB, Chandrakasan G. Influence of Aloe vera on healing of dermal wounds in diabetic rats. J Ethnopharmacol 1998;59:195-201.
10. Shetty S, Udupa S, Udupa L. Evaluation of antioxidant and wound healing effect of alcoholic and aqueous extract of Ocimum sanctum linn in rats. eCAM 2008;5:95-101.
11. Garg VK, Paliwal SK. Wound healing activity of ethanolic and aqous extracts of Ficus benghalensis. J Adv Pharm Technol 2011;2:110-4.
12. Lodhi S, Vadnere G. Relevance and perspectives of experimental wound models in wound healing research. Asian J Pharm Clin Res 2017;7:57-62.
13. Dwivedi D, Dwivedi M, Malviya S, Singh V. Evaluation of wound healing, anti-microbial and antioxidant potential of Pongamia pinnata in wistar rats. J Trad Comple Med 2017;7:79-85.
14. Practical Pharmacology for the Pharmaceutical Sciences by D. Michael Salmon. Edition; 2014.
15. Ravichandran V, Manivannan S. Wound healing potential of transdermal patches containing bioactive fraction from the bark of Ficus racemosa. Int J Pharm Pharm Sci 2015;7:326-32.
16. Mary B, Priya KS, Gnanamani A, Radhakrishan N. Healing potential of Datura alb on burn wound in albino rats. J Ethnopharmacol 2002;83:193-9.
17. Shirwaikar A, Shenoy R, Udupa AL, Udupa SL, Shetty S. Wound healing property of ethanolic extract of leaves of Hyptis suaveolens with supportive role of antioxidant enzymes. Indian J Exp Biol 2003;41:238-41.
18. Odimegwu DC, Ibezim EC, Adikwu Mu, Boniface JAE, Ogbu HI, Esimone CO. Bioassay-tracked temperature-stress-induced chemical degradation of bio-active wound healing, antibacterial extract of Dissotis theifolia stem dispersed in a pharmaceutical cream and ointment. Int J App Res in Nat Prod 2011;1:20-8.
19. Priya KS, Arumugam G, Rathinam B, Wellis A, Babu M. Celosa argentea leaf extract improves wound healing in a rat burn wound model. Wound Rep Regen 2004;12:618-25.
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SABAT, P. K., S. P. PRADHAN, and R. PATRO. “EVALUATION OF EXCISIONAL AND INCISIONAL WOUND HEALING ACTIVITY OF ELECTROHOMEOPATHIC DRUG (SPAGYRIC ESSENCE) GREEN ELECTRICITY IN RATS”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 12, no. 10, Sept. 2020, pp. 72-75, doi:10.22159/ijpps.2020v12i10.38674.
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