A STUDY ON DRUG UTILIZATION EVALUATION AND POTENTIAL DRUG RELATED PROBLEMS IN TYPE-2 DIABETES MELLITUS PATIENTS WITH CO-MORBIDITIES IN A TERTIARY CARE HOSPITAL

PRUDENCE A. RODRIGUES; DAWN TESLIN DAMIEN; MARY CECIL K. T.; NARESH KUMAR M.; RESHMA S. S.; R. SENTHIL KUMAR

doi:10.22159/ijpps.2021v13i3.39425

Authors

PRUDENCE A. RODRIGUES Department of Pharmacy Practice, PSG College of Pharmacy, Department of Endocrinology, Department of General Medicine, PSG Hospitals, Coimbatore, Tamilnadu, India
DAWN TESLIN DAMIEN Department of Pharmacy Practice, PSG College of Pharmacy, Department of Endocrinology, Department of General Medicine, PSG Hospitals, Coimbatore, Tamilnadu, India
MARY CECIL K. T. Department of Pharmacy Practice, PSG College of Pharmacy, Department of Endocrinology, Department of General Medicine, PSG Hospitals, Coimbatore, Tamilnadu, India
NARESH KUMAR M. Department of Pharmacy Practice, PSG College of Pharmacy, Department of Endocrinology, Department of General Medicine, PSG Hospitals, Coimbatore, Tamilnadu, India
RESHMA S. S. Department of Pharmacy Practice, PSG College of Pharmacy, Department of Endocrinology, Department of General Medicine, PSG Hospitals, Coimbatore, Tamilnadu, India
R. SENTHIL KUMAR Department of Pharmacy Practice, PSG College of Pharmacy, Department of Endocrinology, Department of General Medicine, PSG Hospitals, Coimbatore, Tamilnadu, India

DOI:

https://doi.org/10.22159/ijpps.2021v13i3.39425

Keywords:

Antidiabetic drugs, Drug utilization evaluation, Naranjo adverse drug reaction scale, WHO core indicators, Prescribing patterns

Abstract

Objective: The objective of this study is to evaluate prescribing pattern, analyze drug-related problems, identify co-morbidities and complications in Type 2 Diabetes Mellitus patients and also to perform cost analysis of Biguanides, Sulfonylureas, Dipeptidyl Peptidase Inhibitors

Methods: A Prospective observational study was done in General Medicine and Endocrinology Departments of PSG Hospitals. A total of 200 study subjects, including both inpatients and outpatients, above 18 y of age, prescribed with OHAs (Biguanides, Sulfonylureas and DPP4 inhibitors) were included in the study.

Results: Diabetes was more prevalent among males. OHAs were most prescribed in the age group of 51-60 y. Hypertension (71%) was the most common comorbidity and Diabetic neuropathy (23%) was the most common complication found in the patients. Multidrug therapy (72.5%) was most prescribed in diabetic patients, followed by Biguanides. Hypoglycemia was the most prevalent ADR. Cost analysis showed that T. Linagliptin was of high cost and T. Glimepiride being the low cost. Using WHO core indicators prescribing patterns were assessed. Feedback was collected and results were reported to the physicians which showed rational utilization of drugs.

Conclusion: The study on drug utilization conducted in a tertiary care hospital helped us to find out that prescribing trends seems to be progressing towards combination therapy, predominantly two-drug therapy

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