Phytochemical Screening and Evaluation of Antidiarrhoeal Activity of Bunium bulbocastanum Seeds extract in Experimental Wister Rats

  • PITAMBAR KHANAL Tribhubhan university
  • NABINA PAUDEL
  • SUSHANT ARYAL
  • PRAMOD ARYAL

Abstract

Abstract


Aim


The main aim of this study was phytochemical screening and evaluation of antidiarrhoeal activity of Bunim bulbocastanum seeds extracts, to exploit the medicinal use of plant in traditional system of medicine scientifically.


 


Methods


The presence of phytochemical on B.bulbocastanum methanol extract (BBME) was evaluated after the maceration of seed. The extact found to be non toxic up to the dose of 4g/kg.Anti-diarrhoeal activity of the extract was evaluated by castor oil induced intestinal transit and diarrhoeal drooping tests in animal models.


 


Results


The phytochemical test on BBME shows the presence of tannins, carbohydrates, cardiac glycosides, flavonoids and phenol were as anthraquinones, triterpenes, cardenolides and dienolides steroids and saponins were not found. BBME significantly and dose- dependently reduced the gastrointestinal transit in the castor oil induced animal model. Moreover, the average feces weight was significantly reduced by PBME on diarrhoeal drooping tests model. The data was comparable to that of standard antidiarrhoeal drug Loperamide.


 


Conclusion


This study showed that the crude methanol extract of seed of B.bulbocastanum possesses significant antidiarrhoeal property and presence of various secondary metabolites. This justified the antidiarrhoeal use of plant in traditional system of medicine.

Keywords: B.bulbocastanum, phytochemical screening, antidarrhoeal activity, Methanol Extract

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How to Cite
KHANAL, P., N. PAUDEL, S. ARYAL, and P. ARYAL. “Phytochemical Screening and Evaluation of Antidiarrhoeal Activity of Bunium Bulbocastanum Seeds Extract in Experimental Wister Rats”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 13, no. 6, Apr. 2021, doi:10.22159/ijpps.2021v13i6.40035.
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Original Article(s)