DESIGN, SYNTHESIS AND ANTIMICROBIAL STUDIES OF 5-BENZYLIDENE SUBSTITUTED RHODANINE CONTAINING HETEROCYCLES
Objective: The principal objective of the study was to synthesize and evaluate biological activities of novel class of 5-benzylidene substituted rhodanine derivatives as antimicrobial agents.
Methods: All the synthesized compounds (D1-D10) were screened for their antimicrobial activities using microdilution methods as per reported procedure.
Results: All compounds were evaluated against gram positive bacteria:Bacillus cereus MTCC 2756, Staphylococcus aureus MTCC 902, gram negative bacteria: Escherichia coli MTCC 2622, Pseudomonas aeruginosa MTCC 2642 and Klebsiella pneumoniae MTCC 109. Fungal cultures used in the study were Aspergillus niger MTCC 282, Candida albicans MTCC 277, Candida parapsilosis MTCC 6510, Candida tropicalis MTCC 230 and Candida glabrata MTCC 3019. Compound D6 showed good antifungal activity in the MIC range 16μg/ml against Candida tropicalis and Compound D10 showed good antifungal activity in the MIC range 16μg/ml against Candida glabrata. Molecular docking simulations also supports the binding affinity of the ligands with corresponding targets.
Conclusion: On the basis of above results, it can be concluded that the compounds may lead
to the development of more potent antimicrobial drug candidates in near future
This work is licensed under a Creative Commons Attribution 4.0 International License.