H. SABDARIFFA CALYCES ASH: ANTIANXIETY AND ANTIDEPRESSANT ACTIVITY EVALUATION AND PREPARATION OF ITS TABLETS
Objective: Ash and its preparations have been used in Ayurveda for the treatment of various ailments since 7th century AD. Numerous studies suggest that the elements present in ash have significant role in affective disorders. Thus, the present study aimed at evaluating the antianxiety and antidepressant activity of total ash of H. sabdariffa calyces. Further, to facilitate correct and precise dose administration of ash, it was planned to formulate it into tablets.
Method: Powdered calyces were taken in tared silica crucible, and were incinerated at a temperature not exceeding 450 ºC. The resultant ash was cooled and weighed. This was evaluated for antianxiety and antidepressant activity using elevated plus maze and Porsolt’s swim test, respectively. Further, the ash samples were analysed through ICP-MS to know their composition. The ash was formulated into tablets using wet granulation technique, using only organic excipients.
Results: Results indicated that the total ash of H. sabdariffa calyces exhibited significant antianxiety and antidepressant activity at 50 and 100 mg/kg, po, respectively. ICP-MS analysis showed the presence of magnesium, phosphorous, potassium and calcium as major elements. Also, tablets of H. sabdariffa ash exhibited the same level of antianxiety and antidepressant activity as that of the ash.
Conclusion: Magnesium, phosphorous, potassium and calcium have been reported to play significant role in affective disorders, explaining, thereby, as to why ash of H. sabdariffa calyces exhibited antianxiety and antidepressant activity.
This work is licensed under a Creative Commons Attribution 4.0 International License.