ANTIHYPERCHOLESTEROLEMIC AND ANTIATHEROGENIC POTENTIAL OF AQUEOUS EXTRACT OF ADANSONIA DIGITATA STEM BARK INDUCED BY HEATED PALM OIL SUPPLEMENTED WITH EGG YOLK IN RAT
Objective: Poor control of hypercholesterolemia which mediated by overproduction of reactive oxygen species and endothelial dysfunction leads to atherosclerosis. The present study aimed to investigate the antihypercholesterolemic and anti-atherogenic effects of Adansonia digitata (AD.) in heated palm oil/cholesterol supplemented with egg yolk in rats.
Methods: Phytochemical screening of AD. extract was carried out to identify the phytoconstituents. In vitro and in vivo antioxidant potential was evaluated. The antihypercholesterolemic and anti-atherosclerosis activity of AD. was evaluated by inducing hypercholesterolemia in rats with a heated palm oil/cholesterol diet supplemented with egg yolk for 10 weeks. At the end of the induction period, animals were divided into 5 groups of 8 rats each after 6 weeks of induction: Group I (normocholesterolemic rat, NCR), Group II (hypercholesterolemia rat, HCR), Group III (Atorvastatin 2 mg/kg), Groups IV (AD. 100 mg/kg) and V (AD. 200 mg/kg). Hemodynamic parameters, lipid profile, atherogenic indices, and oxidative stress markers were evaluated.
Results: AD. significantly reduced the systolic arterial blood pressure (SBP), diastolic arterial blood pressure (DBP), pulsatile pressure (PP), and heart rate. Plant extract reveals important flavonoids and phenolic contents and has significant in vitro and in vivo antioxidant efficacy. Both doses of 100 and 200 mg/kg of AD.or atorvastatin significantly attenuated the lipid levels, atherogenic indices, and histological abnormalities and significantly (p < 0.01) increased to increase the high-density lipoprotein cholesterol (HDL-c) level.
Conclusion: The aqueous extract of AD. possessed antihypercholesterolemic and anti-atherogenic effects via modulation overproduction of reactive oxygen species and endothelial dysfunction.
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