• PINKEY RAWAL Department of Pharmaceutical Chemistry, East West College of Pharmacy, Bangalore 560091
  • RAMESH C. Department of Pharmacology, East West College of Pharmacy, Bangalore 560091
  • SOMA PRAMANIK Department of Pharmaceutical Chemistry, East West College of Pharmacy, Bangalore 560091




Tephrosia villosa, Anti-ulcer activity, Ethanol, Aspirin Ulcer index, pH, Total acidity, Percentage inhibition and percentage of protected area


Objective: The present research work was designed to investigate the gastroprotective potentials of methanol extract of Tephrosia villosa.

Methods: The aerial parts of Tephrosia villosa were dried under shade, powdered and deffated with petroleum ether and then marc leftover was subjected to methanol extraction using soxhlet apparatus using soxh-let apparatus. Antiulcer activity of methanol extract was determined against stress-induced and aspirin-induced ulcers in experimental animal models. The total number of ulcers formed, ulcer index, percentage inhibition, ulcerated area, protected area, pH and Total acidity were parameters in the study.

Results: Methanol extract of Tephrosia villosa at medium (200 mg/kg) and high (200 mg/kg) could significantly (P<0.01) reduced the total number of ulcers formed, ulcer index, ulcerated area and total acidity in therapeutic groups compared to vehicle control and thereby significantly (P<0.01) increased percentage inhibition of ulcers and protected area which was evident by the significant rise in pH of gastric content. The effect of extracts was dose-dependent and results were comparable to that of standard drug omeprazole.

Conclusion: The results obtained from the present work suggest that the methanol extract of Tephrosia villosa possess significant anti-ulcer potentials against experimentally induced ulcers in albino rats.


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How to Cite

RAWAL, P., R. C., and S. PRAMANIK. “EVALUATION OF GASTROPROTECTIVE EFFECTS OF METHANOL EXTRACT OF TEPHROSIA VILLOSA AGAINST EXPERIMENTALLY INDUCED ULCERS IN WISTAR RATS”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 13, no. 11, Nov. 2021, pp. 20-23, doi:10.22159/ijpps.2021v13i11.41277.



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