LONG TERM FOOD RESTRICTION AND DIABECON ADMINISTRATION AMELIORATES ALLOXAN INDUCED HYPERGLYCEMIA, THYROID DYSFUNCTION AND OXIDATIVE STRESS IN RAT.

  • JYOTI AGRAWAL
  • ANAND KAR

Abstract

The comparative effects of food restriction (FR), Diabecon treatment (DT) and their combined therapy (FR+DT) were studied in the regulation of alloxan induced diabetes mellitus, alterations in thyroid hormones (TH) and oxidative stress. Young diabetic rats were either kept on 50% FR and/or DT (2 gm /Kg body weight) for two months and then alterations in serum glucose, insulin, TH concentrations, hepatic glycogen and pancreatic antioxidants along with oxidative stress markers were evaluated. Significantly increased serum glucose, tissue stress markers with decreased TH, hepatic glycogen (P<0.0001 for all) and pancreatic antioxidants (P<0.05-0.001) were observed in diabetic rats. Rats kept on different therapies exhibited significant (P<0.05) improvements than diabetic rats in all studied parameters. FR+DT group showed significantly more decrease in serum glucose (P<0.05) that FR or DT group, while in other parameters improvement was found to be more or less equally improved in all treated groups. FR appeared to mimic the effects of Diabecon in most of the indices. However, FR+DT appear to be more effective. Possibly both therapies ameliorate diabetes and oxidative stress following some common metabolic pathways.

Keywords: Food restriction, insulin, diabetes, thyroid hormones, oxidative stress, Diabecon

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AGRAWAL, J., and A. KAR. “LONG TERM FOOD RESTRICTION AND DIABECON ADMINISTRATION AMELIORATES ALLOXAN INDUCED HYPERGLYCEMIA, THYROID DYSFUNCTION AND OXIDATIVE STRESS IN RAT.”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 13, no. 7, May 2021, doi:10.22159/ijpps.2021v13i7.41522.
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