Tramadol Hydrochloride, Superdisintegrants, Dispersible tablets, disintegration time, Dissolution Profile, Patient compliance


Objective: The intent and objective of this research work were to find out the most effective superdisintegrants on the basis of disintegration time dissolution rate and other secondary tablet properties among the three mostly used superdisintegrants (Crospovidone, sodium starch glycolate and croscarmellose). This endeavour was initiated to mitigate dysphagia and for better bioavailability of drugs.

Methods: Nine formulations of Tramadol HCl (50 mg) dispersible tablets were fabricated by direct compression process using different concentrations (3%, 5% and 8%) of mentioned superdisintegrants. Dispersible tablets were formulated and evaluated for various parameters such as thickness, hardness, friability, weight variation, disintegration time, drug content and dissolution rate. Then the stability study was carried out on the selected formulation batch to get a conclusion.

Results: Results were interpreted in mean±SD where the value of n is equal to 3. The formulated dispersible tablets were evaluated for their post-compression parameters after achieving the desired pre-compression attributes. In pre-compression evaluation, the flow property and compressibility of powder were checked and the results found to be acceptable of all the nine formulations having an angle of repose less than 19 °, compressibility index in the range of 14.45 to 15.27 and Hausner’s ratio (≤ 1.29). The thickness of the tablets was found to be 4.19 to 4.28 mm. The tablets have optimum hardness just above 4 kg/sq. cm for better sustainability against mechanical stress and the percentage loss on friability found to be less than 1%. The drug content in the tablets of all nine formulations was found to be in the range of 97.48±0.9% to 99.46±0.4%. The wetting time and disintegration time were found to be within 20 sec and 40 sec, respectively, for all nine batches. The dissolution profile showed that more than 97% of the drug were released within 14 min, which is a great achievement in comparison to marketed dispersible tablets. The formulation batch (B2) with crospovidone as superdisintegrant has shown supremacy in tableting properties with better disintegration and dissolution profile. The bioavailability of the drug would be enhanced due to the increment in these parameters. The results of the stability studies of formulation batch (B2) were satisfactory. This batch with crospovidone as a super disintegrant was selected as the best formulation and recommended for scale-up.

Conclusion: The outcome of the research work suggests that the disintegration efficiency of crospovidone is the most among the three super disintegrants and is recommended for the formulation of most effective dispersible tablets of Tramadol Hydrochloride.


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Grond S, Sablotzi A. Clinical pharmacology of Tramadol. Clinical pharmacokinetic 2004; 43(13):879-923.

Madgulkar A, Bhalekar M, Padalkar R. Formulation design and optimization of novel taste masked mouth dissolving tablets of Tramadol having adequate mechanical strength. AAPS PharmSciTech 2009; 10:574-81.

Lachmann L, Liberman H, Kanig J. The theory and practice of Industrial Pharmacy, 3rd edn. Mumbai:Varghese;1987.P.293-79

Cheng R, Guo X, Burnsid B, et al. A review of fast dissolving tablets. Pharma Tech, (North America) 2000; 52-8.

Gordon M, Rudraraju V, Dani K. Effect of the mode of superdisintegrants incorporation on dissolution in wet granulated tablets. J PharmSci 1993; 82:220-6.

Markl D, Zeitler J. A review of disintegration mechanism and measurement techniques. Pharmaceutical Research 2017; 34:890-17.

Nazmi M, Islam SM, et al. Effect of superdisintegrants and their mode of incorporation on disintegration time and release profile of Carbamazepine from immediate release tablet. Journal of Applied PharmSci 2013; 3(05):80-4.

Pawar CV, Mutha SS, Bhinse SV, Borawake PD. Formulation and evaluation of mouth dissolving tablet of Meloxicam using natural superdisintegrants. Asian J Pharm Clin Res 2020; 13:197-03.

Panda S, Hemalatha N, Sankar PU, Baratam SR. Formulation and evaluation of orodispersible tablets(ODTS) of Diclofenac Sodium using superdisinegrants of natural origin. Int J App Pharm 2019; 11:190-7.

Neduri K, Bontha VK, Vemula SK. Different techniques to enhance the dissolution rate of Lovastatin: formulation and evaluation. Asian J Pharm Clin Res 2013; 6:56-60.

Setty CM,Prasad D,et al. Development of fast dispersible tablets: Effect of functionality of superdisintegrants. Indian J.PharmaSci 2008; 70(2):180-5.

Koseki T,Onishi H,Takahasi N,et al. Development of novel fast disintegrating tablets by direct compression using sucrose stearic acid ester as a disintegration accelerating agent. Chemical and Pharmaceutical Bulletin 2008;56(10):1384-88.

Allen LV, Popovich NG, Ansel CH. Ansel´s Pharmaceutical dosage forms and drug delivery systems,9th edn. Philadelephia: 2011.

Nguyen T, Ullmann P. Compounding from basic to modern technology. Australian Journal of Pharmacy online version 2018; 1-9.

Deveswaran R, Bharath S, Basavaraj BV, et al. Concept and techniques of pharmaceutical powder mixing process: A current update. Research J Pharm and Tech 2009; 244-9.

Sandeep D, Charyulu R, Nayak P. Comparative study of superdisintegrants using antiemetic drug as a model. Nitte University Journal of Health Science 2015; 5(1):40-4.

Nasrin N, Asaduzzaman M, Mowla R,et al. A comparative study of physical parameters of selected Ketorolac tromethamine tablets available in the pharma market of Bangladesh. Journal of Applied Pharmaceutical science 2011; 01(08):101-03.

Gennaro A, Remington J. Remington:The science and practice of Pharmacy,19th edn.1995;2:1639-40.

Sunada H, Bi YX, Yonezawa Y,et al. Preparation ,evaluation and optimization of rapidly disintegrating tablets. Powder tech 2002; 122:188-98.

United States Pharmacopoeia.Rockville.MD:27th revision USP Convention, Inc.; 2004:2302.

Zhao N, Augsburger L. Functionality comparison of 3 classes of superdisintegrants in promoting Aspirin tablet disintegration and dissolution. AAPS PharmSciTech 2005; 6:Article79.

Aly AM, et al. Superdisintegrants for solid dispersion. Pharmaceut Technol 2005:68-78

Puttewar TY, Kshirsagar M, et al. Formulation and evaluation of orodispersible tablet of taste masked Doxylamine succinate using ion exchange resin. Journal of king Saud University (science) 2010; 22:229-40.



How to Cite

DASH, G. S., P. N. MURTHY, and K. A. CHOWDARY. “SELECTION AND OPTIMIZATION OF MOST EFFICIENT SUPERDISINTEGRANT FOR THE FORMULATION OF DISPERSIBLE TABLETS OF TRAMADOL HYDROCHLORIDE”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 14, no. 7, July 2022, pp. 21-26, doi:10.22159/ijpps.2022v14i7.43638.



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