• SAMEER H. SAWANT Department of Pharmacology, STES Sinhgad Institute of Pharmacy, Near SKN Medical College, Narhe, Maharashtra, Pune, India 411041
  • AYESHA MUJAWAR Department of Pharmacology, STES Sinhgad Institute of Pharmacy, Near SKN Medical College, Narhe, Maharashtra, Pune, India 411041



Migraine, Abroma augusta L., Nitroglycerin, Bradykinin, Hyperalgesia model


Objective: The present study aimed to evaluate of antimigraine activity of methanolic extract of Abroma augusta L. leaves in laboratory animals.

Methods: The antimigraine activity was evaluated against nitroglycerine (NTG, 10 mg·kg−1, i. p.) and bradykinin (BK, 10 µg, intra-arterial) induced hyperalgesia in rats. Rats were divided randomly into six groups: normal, control, standard (sumatriptan, 42 mg·kg−1, s. c.), and Abroma augusta L. (100,200 and 400 mg·kg−1, p. o.). In the nitroglycerin (NTG) induced hyperalgesia model, rats were pre-treated with standard drug sumatriptan and Abroma augusta L. for 0, 7 and 14 d and tail flick latency were recorded separately in 0-day, 7-day and 14-day pretreatment study. Brain serotonin concentration was also estimated by HPLC method at the end of the study. In bradykinin induced hyperalgesia model the number of vocalizations were recorded as a measure of hyperalgesia in rats.

Results: Abroma augusta L. showed a significant (P<0.001) elevation in the tail-flick latency (at dose 400 mg·kg−1) and body weight (at doses 100, 200, and 400 mg·kg−1) in NTG-induced hyperalgesia model in rats. Further, A. augusta L. (400 mg/kg) showed a significant (P<0.001) increase in brain serotonin concentration compared to NTG control group animal. It showed a significant (P<0.01, P<0.001) reduction in the elevated number of vocalizations at doses (200 and 400 mg·kg−1) in the bradykinin-induced hyperalgesia model in rats.

Conclusion: We concluded that the methanolic extract of Aroma augusta L. possessed an anti-migraine effect in nitroglycerine and bradykinin-induced hyperalgesia model in rats.


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How to Cite

SAWANT, S. H., and A. MUJAWAR. “ANTIMIGRAINE ACTIVITY OF METHANOLIC EXTRACT OF ABROMA AUGUSTA L. IN LABORATORY ANIMALS”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 14, no. 11, Nov. 2022, pp. 54-59, doi:10.22159/ijpps.2022v14i11.45810.



Original Article(s)