SPICY ANTI-CANCER SPICES: A REVIEW
Keywords:Spices, Medicinal plants, Anti-cancer, Herbs
The uses of ethnomedicinal dietary antimutagens and anticarcinogens for human healthcare still remain the most promising approach to the protection of human health and medication system in developing and under developing nations. The plant sources of India provide effective anticancer agents. Spice Herbs have a vital role in the prevention and treatment of cancer. Spices have been used for thousands of years and are known for their flavor, taste and color in the food. Moreover, ethnomedicinal spices used to treat cancer are considerably cheap. Herbal drug treatment can be given to poor people in the rural areas to treat different cancers effectively at an affordable cost. The article reveals the most recent studies on dietary ethnomedicinal spices and their families used to treat various types of cancer.
Globocan. Available from: URL: http: //globocan.iarc.fr/ Pages/fact_sheets_cancer.aspx. [Last accessed on 02 Mar 2015]
Zohara Yaniv Bachrach. Contribution of selected medicinal plants for cancer prevention and therapy. Acta Fac Med 2012;29:117-23.
Abdel-Wahab SI, Ain NM, Abdul BA, Elhassan MM, Ibrahim TAT. Energy-dispersive x-ray microanalysis of elements? Content of medicinal plants used traditionally as anticancer cure. Res J Biol Sci 2009;4:547-9.
Butler MS. The role of natural product chemistry in drug discovery. J Nat Prod 2004;67:2141–53.
Newman DJ, Cragg GM, Snader KM. Natural products as sources of new drugs over the period 1981–2002. J Nat Prod 2003;66:1022–37.
Peter KV. A handbook of herbs and spices. New Delhi: Woodhead Publishing Ltd; 2000.
Buto SK, Tsang TK, Sielaff GW, Gutstein LL, Meiselman MS. Bay leaf impaction in the esophagus and hypopharynx. Ann Intern Med 1990;113:82-3.
Santos FA, Rao. Antiinflammatory and antinociceptive effects of 1.8-cineole a terpenoid oxide present in many plant essential oils. Phytother Res 2000;14:240-4.
Loizzo MR. Cytotoxic ativity of essential oils from labiatae and Lauraceae families against in vitro human tumor models. Anticancer Res 2007;27:3293-9.
Moteki H, Hibasami H, Yamada Y, Katsuzaki H, Imai K, Komiya T. Specific induction of apoptosis by 1,8-cineole in two human leukemia cell lines, but not a in human stomach cancer cell line. Oncol Rep 2002;9:757-60.
Berrington D, Lall N. Anticancer activity of certain herbs and spices on the cervical epithelial carcinoma (HeLa) cell line. J Evidence-Based Complementary Altern Med 2012. doi.org/10.1155/2012/564927. [Article in Press]
Saab AM, Guerrini A, Zeino M, Wiench B, Rossi D, Gambari R, et al. Laurus nobilis L. seed extract reveals collateral sensitivity in multidrug-resistant p-glycoprotein-expressing tumor cells. Nutr Cancer 2015;67:664-75.
Komiya T, Yamada Y, Moteki H, Katsuzaki H, Imai K, Hibasami H. Hot water soluble sesquiterpenes [anhydroperoxy-costunolide and 3-oxoeudesma-1,4,11triene-12,6alpha-olide] isolated from laurel (Laurus nobilis L.) induce cell death and morphological change indicative of apoptotic chromatin condensation in leukemia cells. Oncol Rep 2004;11:85-8.
Menon KS, Nair MK, Sharma OP. Preliminary report on the performance of black pepper on non living standards. Indian Spices 1982;19:3-5.
Singh YN. Kava an overview. J Ethanopharmacol 1992;37:18-45.
Manoharan S, Balakrishnan S, Menon VP, Alias LM, Reena AR. Chemopreventive efficacy of curcumin and piperine during 7, 12 dimethylbenz[a]anthracene induced buccal pouch carcinogenesis. Singapore Med J 2006;50:139-46.
El Hamss R, Idaomar M, Alonso-Moraga A, Munoz-Serra A. Antimutagenic properties of bell and black peppers. Food Chem Toxicol 2003;41:41-7.
Duessel S, Heuertz RM, Ezekiel UR. Growth inhibition of human colon cancer cells by plants compounds. Clin Lab Sci 2008;21:151-7.
Tharmalingam N, Kim SH, Park M, Woo HJ, Kim HW, Yang JY, et al. Inhibitory effect of piperine on Helicobacter pylori growth and adhesion to gastric adenocarcinoma cells. Infect Agents Cancer 2014;16:43.
Sunila ES, Kuttan G. Immunomodulatory and Antitumar activity of piper longum Linn. and piperine. J Ethnopharmacol 2004;90:339-46.
Wongpa S, Himakoun L, Soontornchai S, Temchargen P. Antimutagenic effects of piperine on cyclophosphamade induced chromosome aberrations in rat bone marrow cells. Asian Pac J Cancer Prev 2007;8:623-27.
Mona AM, Abo-Zeid, Ayman A, Farghaly. The anti-mutagenic activity of piperine against mitomycine C induced sister chromatid exchanges and chromosomal aberrations in mice. Nat Sci 2009;7:72-8.
SN Mishra, PC Tomar, N Lakra. Medicinal and food value of Capparis-a harsh terrain plant. Indian J Tradit Know 2007;6:230-8.
Özcan M, Akgül A. Influence of species, harvest date and size on composition of capers (Cap¬paris spp.) flower buds. Nahrung 1998;42:102-5.
Kulisic-Bilusic T, Schmöller I, Schnäbele K, Siracusa L, Ruberto G. The anticarcinogenic potential of essential oil and aqueous infusion from caper (Capparis spinosa L.). Food Chem 2012;132:261–7.
Asaad Abdulwahed B AL-Asady, Khesar H Khalil, Sa’adi Saleh M Barwari. Cytotoxic and cytogenetics effects of aqueous, Methanolic and secondary metabolites extracts of Capparis spinosa on tumor cell lines in vitro. Jordan J Biol Sci 2012;5:15-30.
Ji YB, Yu L. N-butanol extract of Capparis spinosa L. induces apoptosis primarily through a mitochondrial pathway involving mPTP open, cytochrome C release and caspase activation. Asian Pac J Cancer Prev 2014;15:9153-7.
RK Johri. Cuminum cyminum and Carum carvi:an update. Pharmacogn Rev 2011;5:63–72.
Amal AI Mekawey, Mokhtar MM, Farrag RM. Antitumor and antibacterial activities of [1-(2-Ethyl, 6-Heptyl) Phenol] from Cyminum Seeds. J Appl Sci 2009;5:1881-8.
Aruna K, Sivaramakrishnan VM. Anticarcinogenic effects of some Indian plant products. Food Chem Toxicol 1992;30:953-6.
Prakash E, Gupta DK. Cytotoxic activity of ethanolic extract of Cuminum cyminum Linn against seven human cancer cell line. Univers J Agric Res 2014;2:27-30.
Gagandeep, Dhanalakshmi S, Méndiz E, Rao AR, Kale RK. Chemopreventive effects of Cuminum cyminum in chemically induced forestomach and uterine cervix tumors in murine model systems. Nutr Cancer 2003;47:171-80.
UP Singh, B Prilhiviraj, BK Sarma, Mandavi Singh, AB Rai. Role of garlic (Allium sativum L.) in human and plant diseases. Indian J Exp Biol 2001;39:310-22.
Londhe VP, Gavasane AT, Nipate SS, Bandawane DD, Chaudhari PD. Role of garlic (Allium Sativum) in various diseases: an overview. J Pharm Res Opin 2011;1:129-34.
Gunadharini DN, Arunkumar A, Krishnamoorthy G, Muthuvel R, Vijayababu MR, Kanagaraj P, et al. Antiproliferative effect of diallyl disulfide (DADS) on prostate cancer cell line LNCaP. Cell Biochem Funct 2006;24:407-12.
Kumar S, Jitendra K, Singh K, Kapoor V, Sinha M, Xess I, et al. Biological properties and characterization of ASL50 protein from aged allium sativum bulbs. Appl Biochem Biotechnol 2015;176:1914-27.
Nkrumah Elie YM, Reuben JS, Hudson A, Taka E, Badisa R, Ardley T, et al. Diallyl trisulfide as an inhibitor of benzo(a) pyrene-induced precancerous carcinogenesis in MCF-10A cells. Food Chem Toxicol 2012;50:2524-30.
Liu Z, Li M, Chen K, Yang J, Chen R, Wang T, et al. S-allylcysteine induces cell cycle arrest and apoptosis in androgen independent human prostate cancer cells. Mol Med Report 2012;5:439-43.
Seki T, Hosono T, Hosono-Fukao T, Inada K, Tanaka R, Ogihara J, et al. Anticancer effects of diallyl trisulfide derived from garlic. Asia Pac J Clin Nutr 2008;17 Suppl 1:249-52.
S Adel, P Prakash. Chemical composition and antioxidant properties of ginger root (Zingiber officinale). J Med Plants Res 2010;4:2674-9.
Ali BH, Blunden G, Tanira MO, Nemmar A. Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): a review of recent research. Food Chem Toxicol 2008;46:409-20.
Prasad S, Tyagi AK. Ginger and its constituents: role in prevention and treatment of gastrointestinal cancer. Gastroenterol Res Pract 2015. doi.org/10.1155/2015/142979. [Article in Press]
Surh YJ, Park KK, Chun KS, Lee LJ, Lee E, Lee SS. Anti-tumor-promoting activities of selected pungent phenolic substances present in ginger. J Environ Pathol Toxicol Oncol 1999;18:131-9.
Rahman S, Salehin F, Iqbal A. In vitro antioxidant and anticancer activity of young Zingiber officinale against human breast carcinoma cell lines. BMC Complementary Altern Med 2011;11:76.
GC/MS investigation of the essential oils Rosmarinus officinalisL. Acta Pharm Hung 1987;57:159-69.
Peng Y, Yuan J, Liu Abdullah S, Abidin SAZ, Murad NA, Makpol S, et al. Ginger extract (Zingiber officinale) triggers apoptosis and G0/G1 cells arrest in HCT 116 and HT 29 colon cancer cell lines. Afr J Biochem Res 2010;4:134-42.
Bhargava S, Malhotra H, Rathore OS, Malhotra B, Sharma P, Batra A, et al. Anti-leukemic activities of alcoholic extracts of two traditional Indian medicinal plants. Leuk Lymphoma 2015;12:1-15.
Begum A, Sandhya S, Syed Shaffath A, Vinod KR, Swapna R, Banji D. An in-depth review on the medicinal flora Rosmarinus officinalis (Lamiaceae). Acta Sci Pol Technol Aliment 2013;12:61-73.
Kim EC, Min JK, Kim TY, Lee SJ, Yang HO, Han S, et al. -Gingerol, a pungent ingredient of ginger, inhibits angiogenesis in vitro and in vivo. Biochem Biophys Res Commun 2005;335:300-8.
Héthhelyi E, Kaposi P, Domonkos J, Kernóczi ZS. GC/MS investigation of the essential oils Rosmarinus officinalis F, Ye J. Determination of active components in rosemary by capillary electrophoresis with electrochemical detection. J Pharm Biomed Anal 2005;39:431-7.
Oluwatuyi M, Kaatz GW, Gibbons S. Antibacterial and resistance modifying activity of Rosmarinus officinalis. Phytochemistry 2004;65:3249-54.
Leal PF, Braga MEM, Sato DN, Carvalho JE, Marques MOM, Meireles MAA. Functional properties of spice extracts obtained via supercritical fluid extraction. J Agric Food Chem 2003;51:2520-5.
Wei FX, Liu JX, Wang L, Li HZ, Luo JB. Expression of bcl-2 and bax genes in the liver cancer cell line HepG2 after apoptosis induced by essential oils from Rosmarinus officinalis. Zhongyaocai 2008;31:877-9.
González-Vallinas M, Molina S, Vicente G, de la Cueva A, Vargas T, Santoyo S, et al. Antitumor effect of 5-fluorouracil is enhanced by rosemary extract in both drug sensitive and resistant colon cancer cells. Pharmacol Res 2013;72:61-8.
Nabekura T, Yamaki T, Hiroi T, Ueno K, Kitagawa S. Inhibition of anticancer drug efflux transporter P-glycoprotein by rosemary phytochemicals. Pharmacol Res 2010;61:259-63.
Petiwala SM, Puthenveetil AG, Johnson JJ. Polyphenols from the Mediterranean herb rosemary (Rosmarinus officinalis) for prostate cancer. Front Pharmacol 2013;4:29.
Tai J, Cheung S, Wu M, Hasman D. Antiproliferation effect of Rosemary (Rosmarinus officinalis) on human ovarian cancer cells in vitro. Phytomedicine 2012;19:436-43.
Kim DH, Park KW, Chae IG, Kundu J, Kim EH, Kundu JK, et al.Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells. Mol Carcinog 2015;8. doi: 10.1002/mc.22353. [Epub Ahead of Print]
Cattaneo L, Cicconi R, Mignogna G, Giorgi A, Mattei M, Graziani G, et al. Anti-proliferative effect of Rosmarinus officinalis L. Extract on human melanoma A375 Cells. PLoS One 2015;10:e0132439.
KC Velayudhan, N Dikshit, M Abdul Nizar. Ethnobotany of turmeric (Curcuma longa L.). Indian J Traditional Knowledge 2012;11:607-14.
Sasikumar B. Genetic resources of curcuma: diversity characterization and utilization. Plant Res 2005;3:230-51.
Wilken R. Curcumin: a review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma. Mol Cancer 2011;10:12.
Horie S. Chemoprevention of prostate cancer: soy isoflavones and curcumin. Korean J Urol 2012;53:665-72.
Balakrishna A, Kumar MH. Evaluation of synergetic anticancer activity of berberine and curcumin on different models of A549, Hep-G2, MCF-7, Jurkat, and K562 cell lines. Biomed Res Int 2015. doi.org/10.1155/2015/354614. [Article in Press]
Sa G, Das T. Anti cancer effects of curcumin: cycle of life and death. Cell Div 2008;3:14.
Ye M, Li Y, Yin H, Zhang J. Curcumin: updated molecular mechanisms and intervention targets in human lung cancer. Int J Mol Sci 2012;13:3959-78.
Shiri S, Alizadeh AM, Baradaran B, Farhanghi B, Shanehbandi D, Khodayari S, et al. Dendrosomal curcumin suppresses metastatic breast cancer in mice by changing m1/m2 macrophage balance in the tumor microenvironment. Asian Pac J Cancer Prev 2015;16:3917-22.
Shah Rajesh Kumar, Das Loveleena, Sangma Godwin. Medicinal property of murraya koenigii-a review. Int Res J Biological Sci 2013;2:80-3,
Xie JT, Chang WT, Wang CZ, Mehendale SR, Li J, Ambihaipahar R, et al. Curry leaf Murraya koenigii Spreng. reduces blood cholesterol and glucose levels in ob/ob mice. Am J Chin Med 2006;34:279-84.
Jain V, Momin M, Laddha K. Murraya Koenigii: an updated review. Int J Ayurvedic Herbal Med 2012;2:607-27.
Kok YY, Mooi LY, Ahmad K, Sukari MA, Mat N, Rahmani M, et al. Anti-tumour promoting activity and antioxidant properties of girinimbine isolated from the stem bark of Murraya koenigii. Molecules2012;17:4651-60.
Mohan S, Abdelwahab SI, Cheah SC, Sukari MA, Syam S, Shamsuddin N, et al. Apoptosis effect of girinimbine isolated from murraya koenigii on lung cancer cells in vitro. J Evidence-Based Complementary Altern Med 2013. doi.org/10.1155/2013/689865. [Article in Press]
Bhattacharya K, Samanta SK, Tripathi R, Mallick A, Chandra S, Pal BC, et al. Apoptotic effects of mahanine on human leukemic cells are mediated through crosstalk between Apo-1/Fas signaling and the Bid protein and via mitochondrial pathways. Biochem Pharmacol 2010;79:361-72.
Chakraborty M, Nath AC, Khasnobis S, Chakraborty M, Konda Y, Harigaya Y, et al. Carbazole alkaloids from Murraya koenigii. Phytochemistry 1997;46:751-5.
Nutan MTH, Hasnat A, Rashid MA, Antibacterial and cytotoxic activities of Murraya koenigii. Fitoterapia 1998;69:173-5.
Roy MK, Thalang VN, Trakoontivakorn G, Nakahara K. Mechanism of mahanine-induced apoptosis in human leukemia cells (HL-60). Biochem Pharmacol 2004;67:41-51.
Vaibhavi Jakhetia, Rakesh Patel, Pankaj Khatri, Neeraj Pahuja, Sunil Garg, Anupriya Pandey, et al. Cinnamon: a pharmacological review. J Adv Sci Res 2010;1:19-23.
Leela NK. Cinnamon and cassia. In: Parthasarathy VA, Chempakam B, Zacharia TJ. Editors. Chemistry of spices. Cabi: Wallingford; 2008. p. 124-44.
Senanayake UM, Lee TH, Wills RBH. Volatile constituents of cinnamon (Cinnamomum zeylanicum) oils. J Agric Food Chem 1978;26:822–4.
Huang TC, Fu HY, Ho CT, Tan D, Huang YT, Pan MH. Induction of apoptosis by cinnamaldehyde from indigenous cinnamon Cinnamomum osmophloeum Kaneh through reactive oxygen species production, glutathione depletion, and caspase activation in human leukemia K562 cells. Food Chem 2007;103:434–43.
Jayaprakasha GK, Rao LJ. Chemistry, biogenesis, and biological activities of cinnamomum zeylanicum. Crit Rev Food Sci Nutr 2011;51:547–62.
Bhattacharjee S, Rana T, Sengupta A. Inhibition of lipid peroxidation and enhancement of GST activity by cardamom and cinnamon during chemically induced colon carcinogenesis in Swiss albino mice. Asian Pac J Cancer Prev 2007;8:578–82.
Assadollahi V, Gholami M, Zendedel A.C. zeylanicum aqueous extract induced apoptosis in the human myelocytic leukemia cell line (THP-1). Bratisl Lek Listy 2015;116:132-5.
Jeong HW, Han DC, Son KH, Han MY, Lim JS, Ha JH, et al. Antitumor effect of the cinnamaldehyde derivative CB403 through the arrest of cell cycle progression in the G2/M phase. Biochem Pharmacol 2003;65:1343–50.
Lu J, Zhang K, Nam S, Anderson RA, Jove R, Wen W. Novel angiogenesis inhibitor activity in cinnamon extract blocks VEGFR2 kinase and downstream signaling. Carcinogenesis 2010;31:481–8.
Kwon BM, Lee SH, Cho YK, Bok Seung SH, Youn MR, Chang SI. Synthesis and biological activity of cinnamaldehydes as angiogenesis inhibitors. Bioorg Med Chem Lett 1997;7:2473–6.
Cabello CM, Bair WB, Lamore SD, Ley S, Bause AS, Azimian S, et al. The cinnamon-derived Michael acceptor cinnamic aldehyde impairs melanoma cell proliferation, invasiveness, and tumor growth. Free Radical Biol Med 2009;46:220–31.