THERAPEUTIC ADVANCEMENTS IN MANAGEMENT OF IRON OVERLOAD–A REVIEW

  • Priyanka Tyagi Centre for Biomedical Engineering, Indian Institute of Technology, New Delhi, P. O. Box 110016, India
  • Yougesh Kumar Department of Zoology, DAV (PG) College, Muzaffarnagar, C. C. S. University, Meerut, U. P
  • Dikshi Gupta Centre for Biomedical Engineering, Indian Institute of Technology, New Delhi, P. O. Box 110016, India
  • Harpal Singh Centre for Biomedical Engineering, Indian Institute of Technology, New Delhi, P. O. Box 110016, India
  • Amit Kumar Institute of Nuclear Medicine and Allied Sciences, DRDO, New Delhi, P. O. Box 110054, India

Abstract

Removal of excess of free iron, produced under certain physiological conditions in human body, has always been of great concern for therapists worldwide. A number of naturally occurring and synthetic ligands are being explored for maximal iron decorporation, enhanced patient compliance and minimal side effects. Siderophores are the most important class of currently used chelators and few of them are approved for treating iron overload. This review focuses on the developments taking place in the field of iron overload treatment to find the most novel, efficient and safest iron decorporating agent. The importance of many natural and synthetic iron scavengers, having potential for clinical application in the treatment of iron overload and their associated side effects, are discussed along with the currently followed methods. Special emphasis is given to review the status of new ligands, combination therapy and methodologies adopted for overcoming limitations of existing therapeutic agents for treatment of different iron overload disorders.

 

Keywords: Iron chelation, Iron overload, Phlebotomy, Siderophores, Deferasirox

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Author Biography

Amit Kumar, Institute of Nuclear Medicine and Allied Sciences, DRDO, New Delhi, P. O. Box 110054, India
SCIENTIST D, NUCLEAR MEDICINE

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Tyagi, P., Y. Kumar, D. Gupta, H. Singh, and A. Kumar. “THERAPEUTIC ADVANCEMENTS IN MANAGEMENT OF IRON OVERLOAD–A REVIEW”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 8, no. 8, July 2015, pp. 35-44, https://innovareacademics.in/journals/index.php/ijpps/article/view/6149.
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