A PHARMACOLOGICAL COMPREHENSIVE REVIEW ON ‘RASSBHARY' PHYSALIS ANGULATA (L.)
Keywords:
Physalis angulata (L), Cytomorphology, Phytochemistry, Ethnobotany, Biological activitiesAbstract
The present review article reveals the importance of species Physalis angulata (L.) of the genus Physalis (L.) distributed worldwide including India. Physalis species are perennial, erect and variously having toothed or lobed leaves. Physalis angulata (L.) belongs to the family Solanaceae, includes about 120 species with different and specific herbal characters. On the basis of these herbal characters, the plant is traditionally used as medicine to cure various disorders like asthma, kidney, bladder, jaundice, gout, inflammations, cancer, digestive problems and diabetes etc. P. angulata is a source of the variety of phytoconstituents like phytosteroles, withangulatin A, a variety of physalins and flavonol glycoside etc. The plant extracts from the different parts having different pharmacological activities such as anti-cancerous, immunomodulatory, anti-diabetic, diuretic and anti-bacterial. In this article cytomorphological, phytochemical, biological activities and ethnobotanical inputs have been extensively recorded for P. angulata (L.).
Downloads
References
Zhang J, Yulong H, Tiande H, Yunpu W. Effect of Azadirachta indica leaf extract on serum lipid profile changes in normal and streptozotocin induced diabetic rats. Afri J Biomed Res 2005;8:101-4.
Januario A, Filho E, Pietro R, Kashima S, Sato D, Franca S. Anti-mycobactrial physalins from Physalis angulata L. (Solanaceae). Phytother Res 2002;16:445-8.
Smith. Albe Flora Vitiensis nova: a new floura of Fiji. National Tropical Botanical Garden, Lawai, Kauai, Hawaii; 1991;5. p. 626.
Soares MB, Bellintani MC, Ribeiro IM, Tomassini TC, Ribeiro dos Santos R. Inhibition of macrophage activation and lipo polysaccaride induce death by seco-steroids purified from Physalis angulata L. Eur J Pharmacol 2003;459:107â€12.
Perez R, Perez A, Garcia M, Sossa H. Neural pharmacological activity of Solanum nigrum fruit. J Ethnopharmacol 1998; 62:43â€48.
Lin YS, Chiang HC, Kan WS, Hone E, Shih SJ, Won MH. Immunomodulatory activity of various fractions derived from Physalis angulata L. extract. Am J Chin Med 1992;20:233â€43.
Chiang HC, Jaw SM, Chen CF, Kan WS. A noval cytotoxic flavonoid glycoside from Physalis angulata. Anticancer Res 1992a;12:837â€43.
Ismail N, Alam M. A novel cytotoxic flavonoid glycoside from Physalis angulata. Fitoterapia 2001;72:676â€9.
Bastos T, Silveira A, Salgado G, Picanco W, Nascimento M. Physalis angulata extracts exerts anti-inflammatory effects in rats inhibiting different pathways. J Ethnopharmacol 2008;118:251-64.
Mahalakshami A, Nidavani R. Physalis angulata L.: An ethanoparmacological review. Indo Am J Pharm Res 2014;4(3):1479-86.
Lydia G, Rao K. A new cytotype of Physalis angulata L. Chromosome Inf. Serv 1982;32:3–4.
Husaini H, Iwo G. Cytomorphological studies in some weedy species of the family Solanaceae from Jos Plateau, Nigeria. Feddes Report 1990;101:41–7.
Ganapathi A, Sudhakaran S, Kulothungan S. The diploid taxon in Indian natural populations of Physalis L. and its taxonomic significance. Cytologia 1991;56:283–8.
Venkateswarlu J, Rao K. Morphology of the pachytene chromosomes of Physalis angulata. Cytologia 1979A; 44:557–60.
Pedrosa A. Citogenética de angiospermas coletadas em Pernambuco–V. Acta Bot 1999;13(1):49–60.
Puente L, Pinto-Munoz C, Castro E, Cortes M. Physalis peruviana Linnaeus, the multiple properties of a highly functional fruit: A review. Food Res Int 2011;44:1733-40.
Lavie D, Glotter E, Shvo Y. Constituents of Withaniasomnifera Dun. III. The side chain of withaferin A. J Org Chem 1965;30:1774–8.
Kelly K, Quinn L, Steve C, Kirsten B, Hillary L, Mark C, et al. The ethnobotany and ethnopharmacology of wild tomatillos, Physalis longifolia Nutt and related Physalis Species. Econ Bot 2012;20(10):1-13.
Lijuan S, Jianwen L, Ping L, Youjun Y, Lei M, Lihong H. Immunosuppression effect of withangulatin A from Physalis angulata via hemeoxygenase 1-dependent pathways. Pro Biochem 2011;46:482-8.
Elisalva G, Milena L, Luana S, Ivon R, Therezinha C, Ricardo S, et al. Activity of physalins purified from Physalis angulata in in-vitro and in vivo models of cutaneous leishmaniasis. J Antimicrob Chemother 2009;4:84–7.
Cassady J, Suffness M. Terpenoid antitumor agents, in anticancer agents based on natural products. Cassady J, Douros J, Eds. Academic Press: New York; 1980. p. 201-69.
Dinam L, Sarker S, Sik V. 28-hydroxywithnolide E from Physalis peruviana. Photochem 1997;44:509-12.
Zhang H, Samadi A, Gallaghar R, Araya J, Tong X, Day V, et al. Cytotoxic withanolide constituents of Physalis longifolia. J Nat Prod 2011;74(12):2532-44.
Samadi K, Bazzill J, Zhang X, Gallagher R, Zhang H, Gollapudi R, et al. Novel withanolides target medullary thyroid cancer through inhibition of both RET phosphorylation and the mammalian target of rapamycin pathway. Surgery 2012;152(6):1238-47.
Zhang H, Samadi A, Cohen M, Timmermann B. Anti-proliferative withanolides from the Solanaceae: A structure activity study. Pure Appl Chem 2012;84:1353-67.
Kelly K, Quinn L, Steve C, Kirsten B, Hillary L, Mark C, et al. The ethnobotany and ethnopharmacology of wild tomatillos, Physalis longifolia Nutt, and related Physalis Species. Econ Bot 2012;20(10):1-13.
Lijuan S, Jianwen L, Ping L, Youjun Y, Lei M, Lihong H. Immunosuppression effect of withangulatin A from Physalis angulata via hemeoxygenase 1-dependent pathways. Process Biochem 2011;46:482-8.
Choi K, Murillo G, Su B, Pezzuto J, Kinghorn A, Mehta R. Ixocarpalactone A isolated from the Maxican tomatillo shows potent anti-proliferative and apoptotic activity in colon cancer cells. FEBS J 2006;273:5714-23.
Todd. Martindales: The extra pharmacopeia; 1985.
Zaki Y, El-Alfy T, Gohary E. Study of withanolides, physalins, antitumor and antimicrobial activity of Physalis peruviana L. Egypt J Pharm Sci 1987;28:235-45.
Chiang C, Jaw S, Chen C, Kan W. Antitumor agent, physalin F from Physalis angulata L. Anti-Cancer Res 1992a;12:837-44.
Chiang C, Jaw S, Chen P. Inhibitory effects of physalin B and physalin F on various human leukemia cells in vitro. Anti-Cancer Res 1992b;12:1155-62.
Bastos G, Santos A, Ferreira V, Costa A, Bispo C, Silveira A, et al. J Anti-nociceptive effect of the aqueous extract obtained from roots of Physalis angulata L. on mice. J Ethnopharm 2005;103:241-5.
Hseu C, Wu R, Chang W, Kumara S, Linb K, Huang Y, et al. Inhibitory effects of Physalis angulata on tumor metastasis and angiogenesis. J Ethnopharm 2011;135:762-71.
Vessal M, Mehrani H, Omranni G. Effects of an aqueous extract of Physalis alkekengi fruit on estrus cycle, reproduction and uterine creatin kinase BB-isozyme in rats. J Ethanopharmacol 1991;34:69-78.
Vessal M, Yazdanian M. Comparison of effects of an aqueous extract of Physalis alkekengi fruits and/or various doses of 17-β-estradiaol on rat estrous cycle and uterine glucose 6-phosphate dehydrogenase activity. Comp Biochem Physiol 1995a;112(2):229-36.
Vessal M, Mostafavi Z, Kooshesh. Age and sex dependence on the effects of an aqueous extract of Physalis alkekengi fruits on rat hepatic glucose 6-P dehydrogenase activity. Comp Biochem Physiol 1995b;111(4):675-80.
Vessal M, Rasti, Kooshesh. Modulation of pituitary and basomedial hypothalamic lysyl-aminopeptidase activities by β-estradiol and/or an aqueous extract of Physalis alkekengi fruits. Comp Biochem Physiol 1996;115 (2):267-71.
Lin Y, Chiang H, Kan W, Hone E, Shih S, Won M. Immunomodulatory activity of various fractions derived from Physalis angulata L extract. Am J Chin Med 1992;20(3-4);233-43.
Kumar S, Kishor G, Sindhupriya S. In vitro anti-inflammatory and anti-arthritic activity of leaves of Physalis angulata L. Int J Ind Res 2011;2:211-3.
Milena B, Moema B, Ivone M, Therezinha C, Ricardo R. Inhibition of macrophage activation and lipopolysaccharides-induced death by seco-steroids purified from Physalis angulata L. Eur J Pharmacol 2011;459:107-12.
Sateesh P, Porika R, Mamidala E. Phytochemical analysis and in vitro anti-diabetic activities of Physalis angulata fruit extracts. NJIRM 2014;5(2):34-8.
Abo K, Lawal I. Anti-diabetic activity of Physalis angulata extracts and fractions in alloxan-induced diabetic rats. J Adv Sci Res 2013;4(3):32-6.
Oladele M, Ode J, Akande G, Ogunbodede M, Simon K. Effects of ethanolic root extracts of Physalis angulata on alloxan induced diabetic rats. Int JAPS BMS 2013;2(2):95-100.
Ying Wu S, LiiLeu Y, Ling Chang Y, Shung Wu, Chung Kuo P, Ren Liao, et al. Physalin F Induces cell apoptosis in human renal carcinoma cells by targeting NF-kappa B and generating reactive oxygen species. Plus One 2012;7(7):1-10.
Donker A, Glover R, Boateng J, Gakpo V. Antibacterial activity of the fruit extract of Physalis angulata and its formulation. J Med Biomed Sci 2012;1(4):21-6.
Osho A, Adetunji T, Fayemi O, Moronkola O. Antimicrobial activity of essential oils of Physalis angulata L. Afr J Trad Comp Altern Med 2010;7(4):303-6.
Jyothibasu T, Ramana K, Thalla S, Thalla S. Anti-asthmatic activity of alcoholic extract of Physalis angulata induced by ovalbumin. Am J Pharm Tech Res 2012;2(6):1832-4.
Santos J, Tomassini T, Xavier, Ribeiro M, Melissa S, Zenildo F. Molluscicidal activity of Physalis angulata L. extracts and fractions on Biomphlaria tenagophila (d’Orbigny, 1835) under laboratory conditions. Mem Inst Oswaldo Cruz 2003;98(3):425-8.
Nanumala S, Kishore G, Chinnalalaiah R, Sriram C. Evaluations of diuretic activity of methanolic extract of Physalis angulata L. leaves. Int J Pharm Sci Rev Res 2012;16;2:40.
Lusakibanzaa M, Mesiaa G, Tonaa G, Karemereb S, Lukukab A, Titsc M, et al. In-vitro and in-vivo anti-malarial and cytotoxic activity of five plants used in Congolese traditional medicine. J Ethnopharmacol 2010;129(3):398-402.
Murali T, Vadluri R, Kumar M. In vitro determination of anti-oxidant activity of Physalis angulata. Int J Pharm Biol Sci 2013;4(3):541-9.
Lorenzi H, Nova Odessa. Plantasdaninhas do Brasil. Nova Odessa, S-ao Paulo, Brasil; 1982. p. 372.
Heish T, Huang Y, Lin Y, Chung G. Physalis angulata induced G2/M phase arrest in human breast cancer cells. Food Chem Toxicol 2006;44:974-83.
Ferreyra R. Flora invasora de los cultivos de pacallpi y tingomaria; 1970.
Rutter A. Catalogo de plantasutiles de la Amazonia peruana institutol inguistico de veranoyarinacocha Peru; 1990.
Lawal O, Uzokwe E, Lgboanugo I, Adio F, Awuson A, Nwogwugwu, et al. Ethno-medical information on collection and identification of some medicinal plants in research institutes of South-west Nigeria. Afr J Pharm Pharmacol 2010:4(9):32.
Dokosi B. The herbs of Ghana. Ghana Universities Press, Accra; 1998.