A COMPARATIVE STUDY ON THE EFFECT OF FLUOROQUINOLONES IN EXPERIMENTAL SEIZURES ON WISTAR RATS: AN ACUTE STUDY


Aiswarya Aravind, Gopalakrishna H N, Ramya Kateel, Mohandas Rai, Deepthi Shridhar, Reefa Alina D'souza

Abstract


Objective: To compare the convulsive profile of three different Fluoroquinolones namely Ciprofloxacin, Levofloxacin and Ofloxacin using Maximal Electro Shock (MES) as an experimental seizure model.

Methods: Wistar rats were divided into 8 groups with 6 animals each. Group I was administered Gum acacia 1 % solution (control), Group II with Standard drug, Sodium Valproate and Group III-VII received 25 mg/kg and 50 mg/kg of Ciprofloxacin, Levofloxacin and Ofloxacin each respectively. After 45 min of administration of drugs, animals were subjected to MES.

Results: Ciprofloxacin prolonged various phases of MES, Ciprofloxacin 50 mg/kg group increased Tonic Hindlimb Extensor (THE) duration by 91% compared to the control group which was statistically significant. Levofloxacin group exhibited pro convulsive activity which was not significant. Ofloxacin 50 mg/kg group exhibited 80% reduction in the duration of tonic hind limb extensor phase and early recovery phase compared to control group (4.2±1.09 s and 169.33±5.3 s) respectively, proven statistically significant. Ofloxacin group exhibited anticonvulsant like activity.

Conclusion: Fluoroquinolones are the popular class of antimicrobials used in a variety of infections. However, conflicting experimental evidence regarding central neurotoxicity especially seizures, complicate their use and required further investigation. Our results suggest that older generation Fluoroquinolones like Ciprofloxacin exhibits significant dose-dependent pro convulsive activity. Hence, their use must be judiciously restricted in patients with predisposing epileptogenic factors. Levofloxacin had no significant pro convulsant activity. Ofloxacin on higher dose appears to be protective exhibiting an anticonvulsant like activity. Hence, if need be, newer generation Fluoroquinolones should be preferred.

 


Keywords


Fluoroquinolones, Ciprofloxacin, Levofloxacin, Ofloxacin, MES, Anticonvulsant

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About this article

Title

A COMPARATIVE STUDY ON THE EFFECT OF FLUOROQUINOLONES IN EXPERIMENTAL SEIZURES ON WISTAR RATS: AN ACUTE STUDY

Keywords

Fluoroquinolones, Ciprofloxacin, Levofloxacin, Ofloxacin, MES, Anticonvulsant

Date

26-06-2015

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 7, Issue 8, 2015 Page: 305-308

Online ISSN

0975-1491

Statistics

188 Views | 121 Downloads

Authors & Affiliations

Aiswarya Aravind
Department of Pharmacology, A J Institute of Medical Sciences and Research Center, Mangalore, India 575004
India

Gopalakrishna H N
Department of Pharmacology, A J Institute of Medical Sciences and Research Center, Mangalore, India 575004
India

Ramya Kateel
Department of Pharmacology, A J Institute of Medical Sciences and Research Center, Mangalore, India 575004
India

Mohandas Rai
Department of Pharmacology, A J Institute of Medical Sciences and Research Center, Mangalore, India 575004
India

Deepthi Shridhar
Department of Pharmacology, A J Institute of Medical Sciences and Research Center, Mangalore, India 575004
India

Reefa Alina D'souza
Department of Pharmacology, A J Institute of Medical Sciences and Research Center, Mangalore, India 575004
India


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