• S. Priya P. G. Department of Biotechnology, S. T. E. T. Women’s College, Mannargudi, Tamil Nadu, India
  • S. Nethaji P. G and Research Department of Biochemistry, Marudupandiyar College, Vallam, Thanjavur, Tamil Nadu, India


Objective: To evaluate the antipyretic effect of the ethanolic extract of leaf and bark of Diospyros virginiana Linn against brewer yeast induced pyrexia model in albino rats of both sexes was investigated.

Methods: The Pyrexia was induced by subcutaneously injecting 20% w/v brewer's yeast suspension (10 ml/kg) into the animals. After the injection, the rectal temperature of each rat was measured. Paracetamol (150 mg/kg) was used as the standard drug.

Results: The results showed that the ethanol extracts of leaf of Diospyros virginiana possessed significant antipyretic effect compared to the bark extract.

Conclusion: This study provides evidences for the antipyretic activity of Diospyros virginiana which could partly contribute to its ethno medical use.

Keywords: D. virginiana, Brewer yeast, Rectal temperature, Paracetamol


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How to Cite
Priya, S., and S. Nethaji. “ANTIPYRETIC ACTIVITY OF ETHANOLIC EXTRACT OF LEAF AND BARK OF DIOSPYROS VIRGINIANA IN YEAST INDUCED PYREXIA”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 7, no. 9, July 2015, pp. 502-4,
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